Evidence map›Paper›PMID 42713827›Full record

SynthesisUnited European gastroenterology journal2026

EUS-Guided Choledochoduodenostomy Versus Hepaticogastrostomy in Case of Concomitant Gastric Outlet Obstruction Treated by EUS-Guided Gastroenterostomy: A Systematic Review and Meta-Analysis.

Marco Spadaccini, Yen-I Chen, Roberto Leone, Antonella Durante, Maria Margherita Massaro, Giuseppe Vanella, Maria Terrin, Matteo Colombo, Carlo Fabbri, Shannon Melissa Chan and 12 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
In one paragraph

Synthesis in United European gastroenterology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Marco SpadacciniDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.ORCID https://orcid.org/0000-0003-3909-9012
Yen-I ChenDivision of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Quebec, Canada.
Roberto LeoneDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.ORCID https://orcid.org/0009-0005-7438-3221
Antonella DuranteDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.ORCID https://orcid.org/0009-0000-6435-6389
Maria Margherita MassaroDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Giuseppe VanellaPancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute IRCCS, Vita Salute San Raffaele University, Milan, Italy.ORCID https://orcid.org/0000-0001-7280-1761
Maria TerrinGastroenterology and Digestive Endoscopy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.ORCID https://orcid.org/0009-0001-3922-1148
Matteo ColomboGastroenterology and Digestive Endoscopy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.ORCID https://orcid.org/0000-0003-0715-8233
Carlo FabbriForlì-Cesena Hospitals, Gastroenterology and Digestive Endoscopy Unit, AUSL Romagna, Forlì-Cesena, Italy.ORCID https://orcid.org/0000-0003-0670-9910
Shannon Melissa ChanDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0001-6280-4176
Alessandro FugazzaGastroenterology and Digestive Endoscopy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Roberto De SireGastroenterology and Digestive Endoscopy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Jeremie AlbouysGastroenterology Department, Dupuytren University Hospital, Limoges, France.
Silvia CarraraDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Jeremie JacquesResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0003-4105-6804
Daryl RamaiDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2460-7806
Andrea AnderloniGastroenterology and Endoscopy Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID https://orcid.org/0000-0002-1021-0031
Cesare HassanDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Paolo Giorgio ArcidiaconoPancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute IRCCS, Vita Salute San Raffaele University, Milan, Italy.ORCID https://orcid.org/0000-0001-6692-7720
Anthony Yuen Bun TeohDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Alessandro RepiciDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
BRIDGE study group

Funding

The publication fee for this work was covered by the Italian Ministry of Health's "Ricerca Corrente" funding to the IRCCS Humanitas Research Hospital.
6 · The paper itself

Abstract

backgroundBiliary (BO) and gastric outlet obstruction (GOO) frequently complicate pancreatic cancer, often delaying treatment. While EUS-guided gastroenterostomy (EUS-GE) is preferred over duodenal stenting for GOO, the optimal approach for biliary drainage (BD) between EUS-guided choledochoduodenostomy (EUS-CDS) and hepaticogastrostomy (EUS-HGS) remains undefined. This systematic review and meta-analysis aimed to identify the preferred BD strategy in patients undergoing EUS-GE for concurrent GOO and BO.

methodsWe searched Medline, Scopus, and EMBASE up to February 2026. Studies were eligible if they reported outcomes of EUS-CDS or EUS-HGS in patients with malignant BO and concomitant GOO treated by EUS-GE. Outcomes included technical and clinical success, stent dysfunction, and adverse events (AEs) analyzed using a random-effects model. Results were reported as relative risks (RRs) with 95% confidence intervals (CIs).

resultsFive studies were included (128 patients; 45.5% female; mean age range 63.0-73.0 years), with 61 undergoing EUS-CDS and 67 undergoing EUS-HGS. Four studies were European, one American, and one prospective. Technical and clinical success rates were similar between groups (RR 0.96, 95% CI 0.83-1.11; I

conclusionsEUS-CDS and EUS-HGS appear similarly safe and effective for managing malignant BO with concomitant GOO. However, EUS-CDS carries a significantly higher risk of stent dysfunction, potentially delaying critical cancer treatment.

Indexed as

CholedochostomyEndosonographyGastric Outlet ObstructionGastroenterostomyGastrostomyDrainageHumansPancreatic NeoplasmsStentsTreatment OutcomeEUS‐BDEUS‐CDSEUS‐GEEUS‐HGSGOOmalignant double obstruction

Identifiers

PMID42713827
PMCPMC13555797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.