ArticleEnvironmental science. Processes & impacts2026
A toxicokinetic model for gill processes affecting the uptake of perfluoroalkyl acids by freshwater fish.
Article in Environmental science. Processes & impacts, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Perfluoroalkyl acids (PFAA) are a well-studied subclass of per- and polyfluoroalkyl substances (PFAS). Some PFAA bioaccumulate in food webs, and fish consumption is an important vector of human exposure. However, mechanistic studies investigating the relative importance of branchial uptake, tissue partitioning, and renal excretion of PFAA in fish are limited. We developed a mechanistic toxicokinetic (TK) model to examine gill transport as a potential rate-limiting step for PFAA uptake and elimination in fish. The model simulates laboratory conditions and explicitly accounts for transport across the aqueous boundary layer (ABL) at the gill epithelial membrane and co-transport with dissolved organic carbon (DOC). Modeled bioconcentration factors (BCFs) for PFAA containing 4-10 perfluorinated carbons (
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