SynthesisSultan Qaboos University medical journal2026
Does Cardiopulmonary Bypass Influence Outcomes in Stage 2 Palliation?
Synthesis in Sultan Qaboos University medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The bidirectional Glenn (BDG) procedure, a key palliative intervention for single-ventricle physiology, is conventionally performed using cardiopulmonary bypass (CPB) despite its associated complications and costs. However, the comparative impact of CPB versus off-pump techniques on perioperative safety, neurological risk and long-term outcomes remains controversial. Therefore, this meta-analysis aimed to determine whether performing the BDG procedure without CPB improves perioperative outcomes (including morbidity, mortality, and neurological events), resource utilisation, and long-term survival compared to the conventional on-pump approach. Methods: This review systematically searched PubMed, EMBASE and Cochrane Central from inception until January 2025 for comparative randomised and observational studies reporting outcomes in patients undergoing the BDG procedure with versus without CPB. The primary outcome was perioperative mortality (≤30 days or discharge); secondary outcomes included operative duration, recovery parameters (ventilation time, vasoactive support, intensive care unit (ICU)/hospital stay) and postoperative complications (infection, bleeding, neurological events, arrhythmias). Results: A total of 5 studies (2 randomised controlled trials, 3 observational studies; N = 339, 55% with CPB, 45% without CPB) were included. Patients had a mean age range of 6-66 months and mean weight of 6-16 kg. Common anomalies included double-outlet right ventricle and tricuspid atresia. Perioperative mortality did not differ significantly between groups (odds ratio [OR] = 1.15, 95% confidence interval [CI] = 0.31-4.20; Conclusion: The findings suggest that, although off-pump BDG procedure is associated with shorter operative and recovery AU: Please provide the accepted date. times than the on-pump approach, it does not demonstrate superior perioperative mortality or hospital discharge outcomes. Given the risk of conversion and lack of extended follow-up in reporting studies, further randomised multicentre studies with standardised outcomes are warranted before off-pump is deemed a superior option.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.