ArticleSynthesis2026
A Stereoconvergent Annulation in the Synthesis of Lysergic Acid.
Article in Synthesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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0 citing papers in PubMed.
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Authors and funding
3 authors.
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Abstract
Several of the most efficient syntheses of the ergoline lysergic acid hinge on a Heck annulation strategy for the construction of the target's central ring. When bearing an ester functionality at C8, results from various research groups have indicated that the stereochemistry of the ester may be important to the overall mechanism of the cyclization. In this report, we aim to deconvolute the nature of this cyclization by presenting a series of experiments that suggest the importance of several factors including the catalyst utilized, base stoichiometry, and reaction time. A mechanistic understanding of this unique Heck reaction gives insight toward how stereochemical resolution can be achieved in the maximization of yield and synthetic practicality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.