ArticleFrontiers in microbiology2026
Seasonal metabolomics and antibacterial activity of
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Seasonal variation can influence plant metabolite composition and modify antimicrobial performance; however, the relationship between seasonal metabolomic changes and antibacterial activity remains poorly understood in many arid-land medicinal plants. To our knowledge, this is the first study to integrate GC-MS metabolomics, antibacterial screening, and phage-extract interaction testing in Methods: Leaf extracts of Results: GC-MS analysis resolved the curated dataset into 350 putatively annotated parent metabolites, and PCA demonstrated clear season-dependent metabolomic separation, with 16 metabolites differing significantly among collection periods. S2 exhibited the broadest diversity of literature-supported antibacterial candidates, including Discussion: Integrated metabolomics-bioactivity analysis identified citronellol and
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