Evidence map›Paper›PMID 42713224›Full record

ArticleChemical science2026

Multivalent cations stabilize DNA duplexes beyond charge neutralization.

Yun-Long Chen, Chen-Chen Zheng, Yan Zhang, Zhi-Jie Tan, Xing-Hua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yun-Long ChenHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University Wuhan 430072 China zjtan@whu.edu.cn zhxh@whu.edu.cn.
Chen-Chen ZhengHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University Wuhan 430072 China zjtan@whu.edu.cn zhxh@whu.edu.cn.
Yan ZhangDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University Wuhan China peneyyan@whu.edu.cn.
Zhi-Jie TanHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University Wuhan 430072 China zjtan@whu.edu.cn zhxh@whu.edu.cn.
Xing-Hua ZhangHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University Wuhan 430072 China zjtan@whu.edu.cn zhxh@whu.edu.cn.ORCID https://orcid.org/0000-0002-9487-191X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multivalent cations are abundant in cells and play essential roles in DNA duplex stability, genome packaging, and DNA-protein interactions. They can also condense DNA, making it challenging to determine their influence on DNA duplex stability. To overcome this challenge, we studied DNA unpeeling at equilibrium under high tension using magnetic tweezers, thereby preventing condensation. Experiments show that DNA duplex stability first increases and then decreases as cation concentration increases and the maximum DNA duplex stability increases with cation valence. The maximum free energy change of DNA was 3.33

Identifiers

PMID42713224
PMCPMC13552422

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.