ArticleInfection and drug resistance2026
Clinical and Microbiological Characteristics of Pulmonary Aspergillosis in Elderly vs Non-Elderly Patients: A tNGS-Based Retrospective Study.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Elderly patients are more susceptible to pulmonary aspergillosis(PA) and exhibit worse clinical outcomes. This study aims to compare the clinical characteristics, pathogen distribution, co-infection patterns, and outcomes of elderly and non-elderly patients with PA diagnosed via targeted next-generation sequencing (tNGS). Methods: This retrospective study included 107 patients with tNGS-confirmed pulmonary aspergillosis admitted to Ruijin Hospital between March 2023 and January 2025. Demographic, clinical, radiological, and laboratory data were extracted from electronic medical records to compare the clinical and microbiological profiles between the elderly (≥65 years) and non-elderly (<65 years) cohorts. Results: A total of 107 patients including elderly (n=64) and non-elderly (n=43) were included retrospectively. The prevalence of invasive pulmonary aspergillosis was significantly higher in the elderly group compared to the non-elderly group (93.8% vs 74.4%). Similarly, the elderly group had significantly higher proportions of overall co-infection (79.7% vs 51.2%), bacterial co-infection (68.8% vs 39.5%), and atypical imaging features such as patchy infiltrates/consolidation (89.1% vs 62.8%) (all Conclusion: Within our study scope, pulmonary aspergillosis in the elderly is characterized by higher mortality, atypical imaging, prevalent bacterial co-infections, and specific laboratory deviations-most notably, diminished lymphocytes and albumin alongside elevated D-dimer and LDH levels. Furthermore, tNGS serves as a valuable adjunctive tool to identify complex mixed pathogens and assist in clinical management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.