ArticleTobacco induced diseases2026
Systemic inflammatory indices and lung cancer risk by smoking and alcohol use in Korean men: A secondary dataset analysis of the Korean Cancer Prevention Study-II.
Article in Tobacco induced diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSystemic inflammation has been implicated in cancer development, but prospective evidence regarding its association with lung cancer risk remains limited. This study evaluated the associations of systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) with lung cancer risk according to smoking status, alcohol drinking status, and their combined exposure patterns in Korean men.
methodsThis secondary dataset analysis utilized data from the Korean Cancer Prevention Study-II (KCPS-II), a nationwide prospective cohort. Among 20167 men, 236 incident lung cancer cases were identified during a median follow-up of approximately 14 years. Adjusted hazard ratios (AHRs) for lung cancer per 1 standard deviation (SD) increase in SII and NLR were estimated using multivariable Cox proportional hazards models adjusted for demographic, lifestyle, liver function, and endogenous antioxidant biomarkers. Analyses were performed in the overall population and stratified by smoking and alcohol status, including concurrent current smokers and drinkers.
resultsHigher SII and NLR were associated with increased lung cancer risk in Korean men, with consistent associations observed among current smokers, current drinkers, and individuals with concurrent current smoking and drinking. In combined exposure analyses, substantially elevated risks were observed among current smokers with high inflammatory marker levels (SII: AHR=3.58; 95% CI: 2.51-5.09; NLR: AHR=3.78; 95% CI: 2.65-5.39). SII showed the strongest association among individuals smoking ≥30 cigarettes/day (AHR=1.39; 95% CI: 1.21-1.60).
conclusionsSystemic inflammatory markers, particularly SII, were associated with lung cancer risk in Korean men, with stronger associations observed among current smokers. These findings suggest that systemic inflammatory status may help identify individuals at elevated risk of smoking-related lung cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.