Evidence map›Paper›PMID 42713134›Full record

ArticleJournal of alloys and compounds2025

Systematic Study of TiC Nanoparticle Effects on the Fatigue Behavior of Zn and Zn Alloys.

Yuxin Zeng, Narayanan Murali, Guan-Cheng Chen, Jingke Liu, Alexander Killips, Chase S Linsley, Yitian Chi, Xiaochun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of alloys and compounds, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuxin ZengDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA.
Narayanan MuraliDepartment of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA.
Guan-Cheng ChenDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA.
Jingke LiuDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA.
Alexander KillipsDepartment of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA.
Chase S LinsleyDepartment of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA.
Yitian ChiDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA.
Xiaochun LiDepartment of Mechanical and Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA.

Funding

Novel Zinc-Nanocomposite Materials for Pediatric Bioresorbable Cardiovascular StentsR01HL143465 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEVI, DANIEL STEVEN, LI, XIAOCHUN · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL143465
6 · The paper itself

Abstract

Zinc (Zn) is a promising material for biodegradable implants due to its moderate corrosion rate and superior biocompatibility over magnesium (Mg) and iron (Fe). However, its poor fatigue performance limits broader applications. While nanoparticles were discovered to enhance the fatigue performance of metals, the mechanisms remain underexplored. This study investigates nanoparticle-enabled mechanisms for fatigue improvement in Zn. Specifically, the microstructure, tensile, and fatigue performance of pure Zn and Zn nanocomposites containing 1 vol. % and 2 vol. % titanium carbide (TiC) nanoparticles were examined. Results demonstrated that TiC nanoparticles significantly enhanced fatigue resistance of Zn at room temperature (RT) and body temperature (BT). The improved fatigue performance was partly attributed to enhanced tensile strength. Further analysis, including Basquin's equation fitting and fatigue fracture surfaces examination, showed that TiC nanoparticles significantly enhance fatigue resistance by refining grain structure, impeding dislocation movement, altering crack propagation pathways, and promoting energy dissipation during debonding. Moreover, nanoparticle incorporation reduced the temperature sensitivity of Zn's fatigue behavior, ensuring more stable performance under elevated temperatures. Additionally, Zn nanocomposites like Zn-Al-Cu-TiC and Zn- Mg-TiC maintained suitable biocompatibility and corrosion rates. These findings highlight TiC nanoparticles as a powerful solution to overcome Zn's fatigue limitations for biodegradable medical devices.

Indexed as

anti-fatigue mechanismbiodegradable Zn alloysnanocompositeTiC nanoparticles

Identifiers

PMID42713134
PMCPMC13552158

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.