Evidence map›Paper›PMID 42713101›Full record

ReviewFrontiers in immunology2026

Multicellular immunosuppressive networks in microsatellite-stable colorectal cancer: CD8+ T cell exclusion, dysfunction, exhaustion, and therapeutic implications.

Zhiyuan Xia, Haining Chen, Yefu Shen, Minghui Lin, Xihua Xie, Hao Shu, Shen Pang, Dongchao Liu, Yunfei Cao, Sen Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhiyuan Xia *Department of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Haining Chen *Department of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yefu ShenDepartment of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Minghui LinDepartment of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xihua XieDepartment of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Hao ShuDepartment of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shen PangDepartment of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Dongchao LiuDepartment of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yunfei CaoDepartment of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Sen ZhangDepartment of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsatellite-stable (MSS) colorectal cancer (CRC), comprising ~85-90% of cases, remains almost universally refractory to PD-1/PD-L1 monotherapy (objective response rate 5-10%), in stark contrast to the marked efficacy of immune checkpoint inhibitors (ICIs) in microsatellite-instability-high (MSI-H) disease. Here we synthesize evidence that CD8

Indexed as

CD8-Positive T-LymphocytesColorectal NeoplasmsAnimalsCancer-Associated FibroblastsHumansMicrosatellite InstabilityMyeloid-Derived Suppressor CellsT-Cell ExhaustionT-Lymphocytes, RegulatoryTumor-Associated MacrophagesTumor MicroenvironmentCD8+ T cell exhaustioncombination immunotherapymicrosatellite-stable colorectal cancermulticellular immunosuppressive networktumor microenvironment spatial architecture

Identifiers

PMID42713101
PMCPMC13551473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.