Evidence map›Paper›PMID 42713007›Full record

ArticleExperimental and therapeutic medicine2026

Generation and evaluation of multimers of anti C-reactive protein Nb and alkaline phosphatase based on three self-assembly peptides.

Honghe Li, Chenchen Zhou, Xiaomei Zhang, Ning Ding, Qiong Wu, Junming Li, Yang Zheng, Xuejun Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Honghe LiDepartment of Laboratory Medicine, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.
Chenchen ZhouDepartment of Laboratory Medicine, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.
Xiaomei ZhangDepartment of Laboratory Medicine, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.
Ning DingDepartment of Laboratory Medicine, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.
Qiong WuDepartment of Laboratory Medicine, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.
Junming LiDepartment of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Yang ZhengDepartment of Laboratory Medicine, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.
Xuejun HuDepartment of Laboratory Medicine, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanobodies (Nbs) have been extensively utilized in medical diagnosis and therapies due to their advantages, such as ease of genetic manipulation and efficient soluble expression in prokaryotic systems. However, enhancing their binding affinity to antigens to match or even exceed that of polyclonal antibodies for high-sensitivity bioassays remains a challenge. Therefore, in the present study, a novel strategy to enhance the binding affinity of antibodies to antigens was developed by fusing an anti-C-reactive protein Nb (CRPNb) to the N-terminus of self-assembling peptides such as right-handed coiled coil [RHCC; derived from a right-handed coiled-coil peptide of an archaebacterium (

Indexed as

C reactive protein nanobodymultimerizationnanobodyself-assembling peptides

Identifiers

PMID42713007
PMCPMC13551084

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.