ArticleSmart molecules : open access2026
pKa engineering of a near-infrared fluorescent probe for sensitive imaging of oxidative stress in atherosclerotic plaques.
Qianqian Yu, Jiahui Liang, Tijian Zhou, Qiaomeng Chen, Xuechun Yan, Zhikang Zheng, Huyou Wang, Jihong Liu, Yi Dong, Wei-Hong Zhu and 1 more
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In one paragraphArticle in Smart molecules : open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Qianqian YuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Jiahui LiangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Tijian ZhouKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Qiaomeng ChenKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Xuechun YanKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Zhikang ZhengKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Huyou WangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.
Jihong LiuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.ORCID https://orcid.org/0009-0001-0060-4002 Yi DongDepartment of Ultrasound Xinhua Hospital Affiliated to Shanghai JiaoTong University School of Medicine Shanghai China.
Wei-Hong ZhuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.ORCID https://orcid.org/0000-0001-9103-166X Qi WangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China.ORCID https://orcid.org/0000-0003-3694-5826 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Reactive oxygen species (ROS) are key mediators in the progression of atherosclerosis, making ROS imaging valuable for evaluating oxidative stress in plaques. However, most activatable fluorescent probes show limited fluorescence enhancement under physiological conditions because their fluorophores are insufficiently ionized at neutral pH, resulting in weak signal output and low sensitivity. To address this issue, we developed a pKa-engineering strategy by introducing electron-withdrawing fluorine atoms at the ortho-positions of the phenolic hydroxyl group to construct the fluorophore DCM-2F-OH. The difluoro substitution lowered the pKa to 6.0, enabling complete ionization and strong near-infrared fluorescence emission at physiological pH. Incorporation of a boronate ester trigger further afforded the activatable ROS probe DCM-2F-B. DCM-2F-B displayed a 12.8-fold fluorescence turn-on response toward ROS, significantly higher than that of the non-fluorinated analog (2.5-fold), along with a low detection limit (0.03 μM) and low cytotoxicity. The probe successfully visualized endogenous ROS in lipopolysaccharide (LPS)-stimulated macrophages and detected elevated ROS levels in aortic valve tissues from apolipoprotein E knockout (ApoE
Indexed as
atherosclerosisnear‐infrared fluorescent probepKa engineeringreactive oxygen species
Identifiers
PMID42712943
PMCPMC13550858
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