ArticleFrontiers in medicine2026
Using the reflux symptom index to quantify throat symptom burden in LPR-screened-negative patients before and during SARS-CoV-2 infection in China: a prospective follow-up study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aimed to quantify throat symptom burden using the Reflux Symptom Index (RSI) in laryngopharyngeal reflux (LPR)-screened-negative patients before and during SARS-CoV-2 infection in the Omicron-dominant period, and to identify factors independently associated with RSI score increase during infection. Methods: This prospective follow-up study enrolled 428 LPR-screened-negative participants with SARS-CoV-2 infection during the Omicron-dominant period (December 2022-March 2023) in China. RSI questionnaires were administered at two time points: pre-infection baseline and follow-up. The second questionnaire was completed ≥4 weeks after infection onset, and participants retrospectively recalled acute symptoms experienced during the first 2 weeks of illness. Paired-samples Results: Mean age was 37.59 ± 11.56 years; 64.7% were female. Mean total RSI score increased significantly from 5.04 ± 5.98 at baseline to 9.68 ± 7.48 during infection (mean ΔRSI = +4.64; Conclusion: SARS-CoV-2 infection during the Omicron-dominant period significantly worsened throat symptoms in LPR-screened-negative patients. Patients presenting with concurrent fatigue, nasal congestion, and muscle pain showed higher RSI increases and may warrant closer clinical attention.
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