Is passive smoking associated with acute stress response? An observational real-world study.

Background: This study aimed to elucidate the potential association between passive smoking and the risk of post-traumatic stress disorder (PTSD) among high-stress rescue workers, including the magnitude of such an association, and to provide a evidence-based references for the early screening, prevention, and management of PTSD risk in high-stress rescue workers. Methods: Using a cross-sectional design, the study distributed self-administered questionnaires to grassroots officers and soldiers. Data from 4,460 valid respondents were analyzed with logistic regression to quantify the association between passive smoking and positive screening under the Acute Stress Disorder (ASD) scale and PTSD Checklist for DSM-5 (PCL-5). Results: Univariate analysis showed that passive smokers had a 2.509-fold higher risk of ASD compared with non-passive smokers (OR = 2.509, 95% CI = 1.621-3.883, Conclusions: Significant correlations were identified between passive smoking and ASD/PTSD across the entire cohort. Specifically, among non-smokers, passive smoking exposure correlated significantly with elevated ASD risk, but its relationship with PTSD risk was indistinct. For the early screening of high-stress rescue populations, particular attention should be paid to documenting passive smoking exposure. Early intervention strategies need to prioritize reinforcing the enforcement of tobacco control policies and creating smoke-free settings, in order to mitigate the risk of ASD and PTSD linked to passive smoking exposure. Trial Registration: Clinical research registration number: ChiCTR1900023441, registered on 27 May 2019.