Association between peak D-dimer levels within 24 hours of admission and the risk of infected pancreatic necrosis in hyperlipidemic acute pancreatitis: a retrospective analysis.

Xuexiao Chen, Lidan Su, Daguan Zhang, Aidi Chen, Xiaoyan Liu

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Xuexiao ChenDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Lidan SuDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Daguan ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Aidi ChenDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Xiaoyan LiuDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The goal of this study is to analyze the relationship between the peak D-dimer levels measured within 24 h of admission and the risk of infected pancreatic necrosis (IPN) in patients with hyperlipidemic acute pancreatitis (HLAP) and to create and validate an early in-hospital risk stratification model of IPN. Methods: The study was conducted as a retrospective study on 286 HLAP patients from January 2023 - June 2025, divided into IPN ( Results: D-dimer, procalcitonin (PCT), MCTSI score, and persistent organ failure (POF) were independent risk factors for IPN (all Conclusion: Elevated peak D-dimer level within 24 h of admission is independently associated with an increased risk of IPN in HLAP patients in a linear positive manner. The early in-hospital risk stratification model comprised of D-dimer, PCT, MCTSI and POF demonstrates additionally good predictive performance, clinical utility and risk stratification during the early course of hospitalization for personalized treatment decision.

Indexed as

D-dimerhyperlipidemic acute pancreatitisinfected pancreatic necrosisnomogrampredictive model

Identifiers

PMID42712372

DOI10.3389/fmed.2026.1903091

PMCPMC13549853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.