SynthesisFrontiers in medicine2026
Prognostic effect of the preoperative albumin-to-globulin ratio bladder cancer: a meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The preoperative albumin-to-globulin ratio (AGR) has emerged as a potential prognostic indicator in various malignancies. However, its specific prognostic value in bladder cancer remains to be fully elucidated. Thus, the association between preoperative the AGR and the prognosis of bladder cancer should be systematically evaluated through a meta-analysis of the available evidence. Methods: A systematic search was performed across major electronic databases (PubMed, Embase, and the Cochrane Library) to identify studies reporting the prognostic significance of AGR in bladder cancer. The primary outcomes were overall survival (OS) and progression-free survival (PFS). Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled to assess the strength of the association. Results: A total of 8 studies involving 8305 patients were included in this meta-analysis. Our pooled results found that a low preoperative AGR was significantly associated with poor CSS (HR = 1.25, 95% CI: 1.11-1.38), PFS (HR = 1.92, 95% CI: 1.35-2.50), RFS (HR = 1.36, 95% CI: 1.09-1.64) compared with a high AGR in patients with bladder cancer. Conclusion: The preoperative AGR is a reliable prognostic factor for bladder cancer, suggesting that it could be integrated into clinical practice for risk assessment.
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