Evidence map›Paper›PMID 42712136›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2026

Microvascular Dysfunction and Redox Imbalance in Long COVID.

Adela Lewandowska, Dominika Sawicka, Aleksandra Jóźwiak, Agata Jędrzejewska, Alicja Braczko, Marzena Romanowska-Kocejko, Marta Żarczyńska-Buchowiecka, Barbara Kutryb-Zając, Marcin Hellmann, Paulina Mierzejewska

Abstract read
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adela LewandowskaDepartment of Biochemistry, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0009-0003-3017-3869
Dominika SawickaDepartment of Biochemistry, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0009-0002-6819-326X
Aleksandra JóźwiakDepartment of Biochemistry, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0009-0003-5727-2402
Agata JędrzejewskaDepartment of Biochemistry, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0000-0002-8219-7497
Alicja BraczkoDepartment of Biochemistry, Medical University of Gdansk, Gdańsk, Poland.
Marzena Romanowska-KocejkoDepartment of Cardiac Diagnostics, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0000-0001-5651-5941
Marta Żarczyńska-BuchowieckaDepartment of Cardiac Diagnostics, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0000-0002-2963-5419
Barbara Kutryb-ZającDepartment of Biochemistry, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0000-0002-3324-9246
Marcin HellmannDepartment of Cardiac Diagnostics, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0000-0003-0403-805X
Paulina MierzejewskaDepartment of Biochemistry, Medical University of Gdansk, Gdańsk, Poland.ORCID https://orcid.org/0000-0003-1363-7951

Funding

Polish Ministry of Science and Higher Education "Excellence Initiative - Research University" 71-01428/K03-0009804/256
6 · The paper itself

Abstract

objectiveEndothelial and microvascular dysfunction are key features of Long COVID. Disturbances in cellular redox balance, reflected by altered nicotinamide adenine dinucleotide (NAD

methodsMicrovascular function was assessed in 36 patients with Long COVID and 47 age-matched controls using FMSF. NADH fluorescence changes during ischemia and hyperemia were analyzed as markers of endothelial responsiveness. NAD

resultsPatients with Long COVID showed impaired FMSF parameters, including blunted ischemic responses and delayed recovery after hyperemia, indicating microvascular dysfunction. These changes were accompanied by a reduced NAD

conclusionsFMSF provides a clinically applicable tool for detecting microvascular dysfunction in Long COVID. NAD

Indexed as

COVID-19MicrocirculationMicrovesselsSARS-CoV-2SkinAgedFemaleHumansHyperemiaMaleMiddle AgedNADOxidation-ReductionPost-Acute COVID-19 SyndromeNADflow‐mediated skin fluorescence (FMSF)Long COVIDmicrovascular dysfunctionredox imbalance

Identifiers

PMID42712136
PMCPMC13554463

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.