ArticlePediatric transplantation2026
Left Lateral Segment Liver Transplantation in Small Infants: Outcomes From a High-Volume Center.
Article in Pediatric transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGraft selection in small infants is challenging due to size mismatch and the associated risk of vascular or biliary complications.
methodsIn this retrospective single-center study, 57 pediatric liver transplants using left lateral segment grafts performed between 2019 and 2024 were analyzed and compared by recipient weight (< 10 kg vs. ≥ 10 kg).
resultsOverall graft survival was 88% in the < 10 kg group and 96% in the ≥ 10 kg group. Patient survival at 1, 2, and 4 years was similar between groups (p = 0.500). The graft-to-recipient weight ratio was significantly higher in smaller recipients (4.64% vs. 2.37%, p < 0.05), and hepatic artery thrombosis occurred only in this group (9%). Biliary complications were comparable between cohorts (27% vs. 30%). Acute cellular rejection (57% vs. 12%, p < 0.001) and 90-day readmissions (57% vs. 27%, p = 0.022) were significantly more common in children weighing ≥ 10 kg.
conclusionIn this selected cohort, left lateral segment transplantation was associated with excellent outcomes across weight groups. Acceptable results in small infants were achieved despite higher GRWR in a specialized setting, supporting LLS grafts as an important option to improve access to timely pediatric transplantation.
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