Evidence map›Paper›PMID 42711959›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Ultrasound-Activated Nanoinhibitors Blocking the Chemo-Immune Checkpoint to Overcome Chemotherapy-Induced Immune Resistance.

Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yunfan Liu *Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0007-4423-7172
Chier Du *Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Leilei ZhuDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Hongjin AnDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Shengzhe HouDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Yi LanDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Xuemei TangDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Min XuDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Peng LuoDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Hua TengDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Hao YangDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.
Xun GuoDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0003-3083-7509
Jianli RenDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-9258-4776
Zhiyi ZhouDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging and Therapy, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, China.

Funding

China Postdoctoral Science Foundation 2025M782415Chongqing Science and Technology & Health Commission Joint Research General Program 2025MSXM048Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University KR2024G006National Natural Science Foundation of China 82171946National Natural Science Foundation of China 82472006National Natural Science Foundation of China 82472011National Postdoctoral Program for Innovative Talents of China BX20250223Pinnacle Disciplinary Group, the Second Affiliated Hospital of Chongqing Medical University 2024205
6 · The paper itself

Abstract

Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy and develops resistance to conventional immune checkpoint inhibitors. Through single-cell database mining and in vitro analysis, we demonstrate that chemotherapy upregulates Xkr8 expression and promotes phosphatidylserine (PS) externalization, which mediates macrophage- and dendritic cell (DC)-intrinsic immunosuppression. To address this, we fabricate an ultrasound-activated nanoinhibitor (Sono-TT8) that co-delivers tirapazamine (TPZ) and siXkr8 using a TiO

Indexed as

chemo‐immunotherapyimmune checkpoint blockadesiRNA and drug co‐deliveryultrasound‐responsive nanomedicine

Identifiers

PMID42711959
PMCPMC13554490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.