Evidence map›Paper›PMID 42711907›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Single-Cell Profiling Reveals Clonally Expanded CX3CR1

Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou and 4 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lin Yan *Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-3518-6082
Erdi Zhang *Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0006-6234-9955
Yuwen Ma *Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0001-2273-3286
Zirui MengDepartment of Laboratory Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-0509-200X
Sisi LiDepartment of Breast Cancer Center, Chongqing University Cancer Hospital, Chongqing, China.
Yimeng RenLKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0009-0008-5141-0823
Xiaohe TianFunctional and Molecular Imaging Key Laboratory of Sichuan Province, Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-2294-3945
Yangyi HeDepartment of Surgery and Surgical Specializations, University of Barcelona, Barcelona, Spain.
Giuseppe BattagliaInstitute for Bioengineering of Catalunya (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID https://orcid.org/0000-0003-3349-6770
Dong ZhouDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-7101-4125
Yun LiaoDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-0829-8986
Binwu YingDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-8077-3908
Jinmei LiDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-7411-8269
Minjin WangDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-7989-0330

Funding

1·3·5 Project for Disciplines of Excellence from West China Hospital of Sichuan University ZYGD23036National Natural Science Foundation of China NSFC 32401233"Qimingxing" Research Fund for Young Talents HXQMX0089
6 · The paper itself

Abstract

Anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E) is a prevalent autoimmune neurological disorder, yet T cell-driven immunopathology and its contributions to therapeutic resistance and fulminant neuroinflammation remain poorly defined. Integrative single-cell multi-omic profiling, combining single-cell RNA sequencing, single-cell T cell receptor (TCR) sequencing, and cellular indexing of transcriptomes and epitopes by sequencing, is applied to systematically map peripheral and cerebrospinal fluid (CSF) immune landscapes in treatment-naïve NMDAR-E patients, with orthogonal validation conducted across independent cohorts via multiparameter flow cytometry and ex vivo NR1 peptide stimulation. Clonally expanded CX3CR1-expressing CD4

Indexed as

anti‐NMDA receptor encephalitisCX3CR1neuroinflammationsingle‐Cell multi‐omicsT cell receptor clonalityT Cells

Identifiers

PMID42711907
PMCPMC13554385

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.