Next-Generation Solid Dispersion of Andrographolide Attenuated Inflammation and Oxidative Stress in an Activated RAW264.7 Macrophage-Based In Vitro Model Relevant to Ulcerative Colitis.

Pawan Devangan, Dinesh Kumar Chandanpalli, Atul Mourya, Jitender Madan

Abstract read

In one paragraph

Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pawan DevanganDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.ORCID http://orcid.org/0000-0002-2858-3653

Dinesh Kumar ChandanpalliDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.ORCID http://orcid.org/0009-0003-3523-1669

Atul MouryaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.ORCID http://orcid.org/0000-0003-1365-8787

Jitender MadanDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India. jitenderpharmacy@gmail.com.ORCID http://orcid.org/0000-0002-1205-7667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) is fundamentally mediated by macrophage-driven immune dysregulation that amplifies mucosal inflammation. Andrographolide (AGD) has potent anti-inflammatory and antioxidant properties; however, AGD shows poor water solubility and bioavailability. To surmount these challenges, next-generation solid dispersion of AGD with soluplus and TPGS was engineered via the solvent evaporation method. Optimized SD8 demonstrated a ~ 7.14-fold upsurge in solubility, 18.78 ± 0.98% drug content, 93.86 ± 3.19% assay, micellar colloid size of 220.5 ± 20.8 nm, and ζ-potential of -4.18 ± 0.03 mV in aqueous dispersion. ATR-FTIR and

Indexed as

Anti-Inflammatory AgentsColitis, UlcerativeDiterpenesInflammationMacrophagesOxidative StressAnimalsAntioxidantsMiceRAW 264.7 CellsSolubilityandrographolideAnti-Inflammatory AgentsAntioxidantsDiterpenesamorphous solid dispersionandrographolideinflammationsolubilityulcerative colitis

Identifiers

PMID42711620

DOI10.1016/j.jddst.2023.104507

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.