Evidence map›Paper›PMID 42711610›Full record

ArticleThe AAPS journal2026

Predicting Cannabidiol Pharmacokinetics in Older Adults Via Physiologically Based Pharmacokinetic Modeling.

Lixuan Qian, Aiden-Hung P Nguyen, Mary F Paine, Zhu Zhou

Abstract read
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In one paragraph

Article in The AAPS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lixuan QianDepartment of Pharmaceutical Sciences, University of the Pacific, Stockton, USA.ORCID http://orcid.org/0000-0003-3137-5529
Aiden-Hung P NguyenDepartment of Pharmaceutical Sciences, Washington State University, Spokane, USA.ORCID http://orcid.org/0009-0007-6159-039X
Mary F PaineDepartment of Pharmaceutical Sciences, Washington State University, Spokane, USA.ORCID http://orcid.org/0000-0002-3331-1839
Zhu ZhouDepartment of Pharmaceutical Sciences, University of the Pacific, Stockton, USA. zzhou@pacific.edu.ORCID http://orcid.org/0009-0000-2051-2239

Funding

Pharmacology CoreU54AT008909 · NCCIH · WASHINGTON STATE UNIVERSITY · PI PAINE, MARY F · 2015 to 2024
$22.4M
Quantifying effects of comorbidities and genetics on cannabinoid exposure in the elderlyR16GM146679 · NIGMS · YORK COLLEGE · PI ZHOU, ZHU · 2022 to 2025
$795k
NCCIH NIH HHS U54 AT008909NIGMS NIH HHS R16 GM146679
6 · The paper itself

Abstract

Cannabidiol (CBD) use continues to increase, particularly among older adults. However, knowledge of CBD disposition in this ever-growing and understudied population, along with the relative contributions of cytochrome P450 (CYP) and uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes to CBD metabolism, remain limited. Inclusion of UGT activators (e.g., alamethicin, MgCl

Indexed as

CannabidiolModels, BiologicalAge FactorsCytochrome P-450 Enzyme SystemGlucuronosyltransferaseHumansCannabidiolCytochrome P-450 Enzyme SystemGlucuronosyltransferasecannabinoidsmetabolitesPBPKpharmacokineticstime-dependent inhibition

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.