Evidence map›Paper›PMID 42711601›Full record

ArticlePurinergic signalling2026

Antagonism of P2X7 receptor function in synovial fibroblasts is a potential therapeutic manipulation in rheumatoid arthritis.

Shi-Yan Zhang, Y Tang, P Illes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shi-Yan ZhangInternational Joint Research Centre On Purinergic Signaling/School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Y TangInternational Joint Research Centre On Purinergic Signaling/School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China. tangyong@cdutcm.edu.cn.
P IllesInternational Joint Research Centre On Purinergic Signaling/School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China. peter.illes@medizin.uni-leipzig.de.

Funding

Sino-German-Center GZ919
6 · The paper itself

Abstract

In a recent article published in Science Advances, Rao et al. reported that synovial fibroblasts (SFs) from patients with rheumatoid arthritis (RA) express higher levels of P2X7 receptors (P2X7Rs) than SFs from patients with osteoarthritis [1]. EVT-401, a highly selective P2X7R antagonist with a marked preference for the human ortholog, inhibited the proliferation of RA SFs isolated from inflamed synovial tissue and maintained in culture for one day. EVT-401 also induced cell-cycle arrest in the G

Indexed as

Arthritis, RheumatoidFibroblastsPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Synovial MembraneAnimalsHumansPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7P2X7 receptorsRheumatoid arthritisSynovial fibroblasts

Identifiers

PMID42711601
PMCPMC13553991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.