Evidence map›Paper›PMID 42711600›Full record

ReviewClinical reviews in allergy & immunology2026

Climate Change-Mediated Temperature Extremes: Effects on the Immune System and Associations with Immune-Related Diseases.

Shengjie Li, Wenqu Tian, Yang Zheng, Yachun Li, Ismail Ogulur, Can Zeyneloglu, Huseyn Babayev, Mohamed Shamji, Kari Nadeau, Cezmi A Akdis and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shengjie Li *Department of Allergy, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, Zhejiang, 310003, China.
Wenqu Tian *Department of Allergy, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, Zhejiang, 310003, China.
Yang ZhengDepartment of Allergy, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, Zhejiang, 310003, China.
Yachun LiDepartment of Allergy, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, Zhejiang, 310003, China.
Ismail OgulurSwiss Institute of Allergy and Asthma, University Zurich, Herman-Burchard Strasse 9, Zurich, Davos, CH-7265, Switzerland.
Can ZeynelogluSwiss Institute of Allergy and Asthma, University Zurich, Herman-Burchard Strasse 9, Zurich, Davos, CH-7265, Switzerland.
Huseyn BabayevSwiss Institute of Allergy and Asthma, University Zurich, Herman-Burchard Strasse 9, Zurich, Davos, CH-7265, Switzerland.
Mohamed ShamjiSwiss Institute of Allergy and Asthma, University Zurich, Herman-Burchard Strasse 9, Zurich, Davos, CH-7265, Switzerland.
Kari NadeauSwiss Institute of Allergy and Asthma, University Zurich, Herman-Burchard Strasse 9, Zurich, Davos, CH-7265, Switzerland.
Cezmi A AkdisSwiss Institute of Allergy and Asthma, University Zurich, Herman-Burchard Strasse 9, Zurich, Davos, CH-7265, Switzerland. akdisac@siaf.uzh.ch.
Yadong GaoDepartment of Allergy, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, Zhejiang, 310003, China. gaoyadong@zju.edu.cn.ORCID http://orcid.org/0000-0003-1251-7608

Funding

National natural science foundation of China 72204214Start-up Research fund by The First Affiliated Hospital of Zhejiang University School of Medicine BQD 2306Zhejiang Clinovation Pride CXTD202501015Zhejiang Provincial Natural Science Foundation of China LQN25H030006Zhejiang Provincial Natural Science Foundation of China LTGY24H260001
6 · The paper itself

Abstract

Climate change exacerbates extreme temperature events, which pose a growing global threat to human health, especially disturbing the immune system and increasing the incidence of immune-related diseases. This review synthesizes the multifaceted links between extreme temperatures and human immune system. Extreme temperatures could activate the neuroendocrine system, trigger the release of cytokines, regulate heat shock proteins (HSPs) and induce epigenetic modifications. The epithelial barrier dysfunction and gut microbiota dysbiosis are involved in the association between extreme temperature and immune system. These immune perturbations increase the risk of allergic diseases, autoimmune disorders and infectious diseases, disproportionately affecting children, elderly, patients with chronic diseases and people living in low-income and geographically vulnerable areas. Noting limitations like insufficient focus on vulnerable groups and static models, this review highlights the urgency of addressing climate-temperature-immunity interactions to guide climate-resilient public health strategies.

Indexed as

Climate ChangeImmune SystemImmune System DiseasesAnimalsCytokinesDisease SusceptibilityEpigenesis, GeneticHumansHypersensitivityTemperatureCytokinesAllergic diseasesClimate changeExtreme temperatureImmune system

Identifiers

PMID42711600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.