ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Mechanical basis of cortical cataract.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAccommodation, the ability of the human eye to adjust focus, declines with age due to progressive lens stiffening. This study hypothesizes that cycles of attempted accommodation and relaxation in presbyopic eyes (≥ 50 years) induces internal deformations in the equatorial cortex of the lens, contributing to cortical cataract formation.
methodsFinite element simulations were performed to evaluate internal strains and stresses in the equatorial cortex of lenses of different ages caused by ciliary body movements during accommodation or attempted accommodation. The models incorporated previously published data on spatial variations in lens stiffness, quantified by shear modulus, and its age-related changes.
resultsIn the 55-year lens model, relaxation after attempted accommodation produced significant shear strain and radial stress concentrations in the equatorial cortex. The locations of these stress and strain concentrations corresponded with cortical cataract sites reported in the literature. The simulations also demonstrated local separations at the cortex-capsule and cortex-nucleus boundaries, consistent with prior in vitro findings. These separations reduced local stress and strain concentrations but may increase cataract risk through damage-repair and scarring.
conclusionsFinite element modeling suggests the possibility that internal deformations generated during attempted accommodation in aging lenses may play a role in cortical cataract development. This suggests a complex interplay between mechanical strain and biological repair mechanisms in age-related lens pathology.
Indexed as
Identifiers
42711572What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.