Evidence map›Paper›PMID 42711571›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Widefield optical coherence tomography angiography of fellow eyes in patients with Coats Disease.

Charlotte Egbring, Sarah Kleemann, Verena Anna Englmaier, Nicole Eter, Jens Julian Storp

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Charlotte EgbringDepartment of Ophthalmology, University of Muenster Medical Center, Domagkstrasse 15, Muenster, 48149, Germany. charlotte.egbring@ukmuenster.de.ORCID http://orcid.org/0009-0006-2582-055X
Sarah KleemannDepartment of Ophthalmology, University of Muenster Medical Center, Domagkstrasse 15, Muenster, 48149, Germany.
Verena Anna EnglmaierDepartment of Ophthalmology, University of Muenster Medical Center, Domagkstrasse 15, Muenster, 48149, Germany.
Nicole EterDepartment of Ophthalmology, University of Muenster Medical Center, Domagkstrasse 15, Muenster, 48149, Germany.
Jens Julian StorpDepartment of Ophthalmology, University of Muenster Medical Center, Domagkstrasse 15, Muenster, 48149, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRecent advances in retinal imaging have revealed vasculostructural alterations in fellow eyes of patients with Coats disease, thereby challenging the traditional concept of Coats disease as a strictly unilateral disorder. To further explore the phenotype of this retinal disease, this study investigated whether subclinical vascular changes can be detected in fellow eyes using Widefield Optical Coherence Tomography Angiography (WF-OCT-A).

methodsThis trial prospectively recruited Coats disease patients as well as age- and sex-matched healthy controls from University Hospital Münster. Participants underwent WF-OCT-A imaging, enabling imaging of large peripheral retinal areas. Imaging analysis was carried out using AngioTool.

resultsNineteen patients with Coats disease and nineteen matched healthy controls were included. Quantitative analysis revealed no significant differences in the superficial capillary plexus (SCP) between fellow eyes and control eyes regarding flow density (p = 0.56), number of junctions (p = 0.79), total vessel length (p = 0.61), average vessel length (p = 0.75), number of endpoints (p = 0.96), or lacunarity (p = 0.41).

conclusionIn this cohort, WF-OCT-A did not identify detectable retinal vascular alterations in clinically unaffected fellow eyes of patients with Coats disease. This finding argues against previously noted prominent subclinical retinal vascular abnormalities in these eyes.

Indexed as

AngioToolFDLacunarityShieldsVascular junctionsWF-OCT-A

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.