ArticleEuropean geriatric medicine2026
The associations between ATN biomarkers and episodic memory diminish as age increases.
Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
purposeThe relationship between age, biomarkers, and cognitive function at advanced ages remains underexplored. By utilizing a naturalistic memory clinic cohort, we aimed to clarify how the A/T/N biomarkers are associated with verbal episodic memory performance and the moderating effect of age.
methodsThis cross-sectional study included 676 patients from memory clinics in the Stockholm metropolitan region, comprised of 141 with Alzheimer's disease dementia, 403 with mild cognitive impairment, and 132 with subjective cognitive impairment. We used weighted least-squares regressions to evaluate the association between episodic memory and the biomarkers and the moderating effect of age.
resultsThere was a significant interaction between age and A (Aβ42), where the negative impact of Aβ42 abnormality on Rey Auditory Verbal Learning (RAVLT) delayed recall was reduced with higher age (β = 0.22, p < 0.001). In addition, a corresponding interaction effect was observed between age and N (MTA) on RAVLT delayed recall (β = 0.13, p < 0.01). Additional exploration analyses showed that at age 80 or older, the ATN biomarkers showed weaker associations with episodic memory performance.
conclusionsAlthough interpretations should be conducted with caution, these findings raise questions about the justification for assessing CSF in patients older than 80 years, given its weak associations with core clinical measures, such as learning and free recall of episodic memory. Further clinical studies are needed to validate these results and also evaluate other core cognitive measures. The naturalistic nature of the memory clinic population, with its clinically driven diagnoses, may help clarify these findings.
Indexed as
Identifiers
42711542What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.