ArticleEuropean journal of nuclear medicine and molecular imaging2026
Patient selection for primary staging with [99mTc]Tc-PSMA SPECT/CT: influence of combined PSA and ISUP grade on detection of metastatic disease.
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to examine the combined influence of initial PSA level (iPSA) and ISUP grade on the detection rates of [99mTc]Tc-PSMA SPECT/CT in patients undergoing primary staging of prostate cancer and to identify selection criteria. PATIENTS AND
methodsIn this retrospective study, 91 patients underwent SPECT/CT following administration of 670 MBq (range, 470-792 MBq) [99mTc]Tc-MIP-1404. Detection rates of the primary tumour, pelvic lymph node metastases and distant metastases were determined together with imaging biomarkers. Univariate and multivariate nominal logistic regression analyses identified predictors of metastatic disease.
resultsBoth iPSA level and ISUP grade were independent predictors of metastatic disease (p
conclusionPatient selection for [99mTc]Tc-PSMA SPECT/CT may be improved by incorporating ISUP grade and iPSA, particularly ISUP grades 4-5 with iPSA > 20 ng/ml and ISUP grades 1-3 with iPSA > 50 ng/ml. Distinct patterns of metastatic spread were observed according to both ISUP grade and iPSA. Where PSMA PET/CT is unavailable, [99mTc]Tc-PSMA SPECT/CT may represent a valuable alternative for primary staging of selected patients with PCa.
Indexed as
Identifiers
42711500What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.