Evidence map›Paper›PMID 42711490›Full record

ArticleNature chemical biology2026

Macrophages transfer functional proteins to their surface during live-cell uptake.

Regan F Volk, Amy C Fan, Sara W Casebeer, Vishnu R Tejus, Andrew C Condon, Bahar Zirak, Nayelis A Manon, Iryna Irkliyenko, Danielle M Torralba, Shao Tao and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Regan F VolkDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6748-719X
Amy C FanDepartment of Pathology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1612-1862
Sara W CasebeerDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8049-0585
Vishnu R TejusDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Andrew C CondonDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Bahar ZirakDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Nayelis A ManonDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Iryna IrkliyenkoHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Danielle M TorralbaThe Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Shao TaoDivision of Surgical Oncology, Department of Surgery, University of California, San Francisco, CA, USA.
Tommaso PolliniDivision of Surgical Oncology, Department of Surgery, University of California, San Francisco, CA, USA.
Vijay RamaniHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3345-5960
Ajay V MakerDivision of Surgical Oncology, Department of Surgery, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8234-2762
Matthew F KrummelDepartment of Pathology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7915-3533
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9648-8949
Balyn W ZaroDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. balyn.zaro@ucsf.edu.ORCID http://orcid.org/0000-0002-8938-9889

Funding

Arnold and Mabel Beckman Foundation Beckman Young Investigator
6 · The paper itself

Abstract

A cell's proteome is assumed to reflect its transcriptional and translational activity. Macrophages regularly acquire xenobiotic material from neighboring cells, which is thought to result in degradation of the material. However, increasing lines of evidence suggest that not all taken up material is degraded and other transfer-like processes also occur. Field standard technologies are unable to rigorously report on precisely how and by whom the macrophage protein repertoire is altered during these interactions, leaving unresolved the extent to which nondegradative processes contribute to altered phenotypes. Here, we leveraged chemical tools and proteomics to show that intact target cancer cell surface proteins are transferred to the macrophage cell surface at functionally impactful levels in a manner associated with live-cell uptake. Widespread acquisition of proteins during cell uptake reengineers the macrophage cell surface proteome and is a transcriptionally silent, cell-nonautonomous process with the potential to alter metabolic uptake.

Identifiers

PMID42711490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.