Evidence map›Paper›PMID 42711457›Full record

ArticleInternational journal of obesity (2005)2026

Intestinal HIF1α is dispensable for bariatric surgery-mediated metabolic benefits but protects against diet-induced obesity and hepatic steatosis.

Chong Cao, Yanyang Liu, Xiaozhuo Tan, Yian Zhao, Huang Jaime, Yuxiao Chu, Mengcheng He, Rong Hua, Qiyuan Yao, Yikai Shao

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Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Chong Cao *Center for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Yanyang Liu *Center for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Xiaozhuo TanCenter for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Yian ZhaoCenter for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Huang JaimeCenter for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Yuxiao ChuCenter for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Mengcheng HeCenter for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Rong HuaCenter for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Qiyuan YaoCenter for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Yikai ShaoCenter for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China. ykshao@fudan.edu.cn.ORCID http://orcid.org/0000-0003-1466-752X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntestinal hypoxia-inducible factor 1α (HIF1α) orchestrates epithelial adaptation to luminal hypoxia and has been linked to metabolic homeostasis, yet its contribution to obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and bariatric surgery-mediated benefits remain unclear.

methodsIn this study, we combined diet-induced models and genetic approaches to interrogate intestinal epithelial HIF1α function in obesity/MASLD progression and in the metabolic improvements elicited by sleeve gastrectomy (SG).

resultsIntestinal epithelial HIF1α deletion did not alter diet-induced weight gain, glucose homeostasis, or the metabolic and hepatoprotective effects of SG under either High-fat diet (HFD) or high-fat/high-fructose diets (HFFD) feeding. Notably, despite largely unchanged systemic metabolic phenotypes, intestinal HIF1α deficiency increased hepatic triglyceride and cholesterol accumulation and reshaped hepatic metabolic gene expression, indicating a selective impact on liver lipid handling. In contrast, activation of intestinal HIF1α protected against diet-induced obesity and hepatic steatosis. 16S rRNA profiling showed that intestinal HIF1α activation was associated with a distinct microbial shift, including enrichment of Ruminococcus and reduction of Desulfovibrio.

conclusionsAlthough activated after SG, intestinal epithelial HIF1α is not required for SG-induced metabolic improvements but exerts context-dependent protection against diet-induced obesity and hepatic steatosis, accompanied by gut microbial remodeling.

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PMID42711457

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