Zinc-finger proteins C3H14 and C3H15 maintain meiocyte identity in flowering plants.

Zhiyu Chen, Meiling Li, Shiqian Yang, Ke Li, Yilin Xin, Xiulian Liu, Yuxuan Guo, Hong Ma, Chenjiang You, Cong Wang and 1 more

Abstract read

PubMed Publisher

In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

How SCREW finds its NUT.Nature plants · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiyu Chen *State Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-3114-0340

Meiling Li *Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, China.

Shiqian Yang *Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, China.

Ke LiGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, China.

Yilin XinGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, China.

Xiulian LiuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, China.

Yuxuan GuoState Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China.

Hong MaDepartment of Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0001-8717-4422

Chenjiang YouGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, China. cjyou@scau.edu.cn.ORCID http://orcid.org/0000-0002-9935-1892

Cong WangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, China. wangc@scau.edu.cn.ORCID http://orcid.org/0000-0002-1647-1072

Yingxiang WangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, China. yxwang@scau.edu.cn.ORCID http://orcid.org/0000-0001-6085-5615

Funding

National Natural Science Foundation of China (National Science Foundation of China) U24A20350

6 · The paper itself

Abstract

In the anthers of flowering plants, the innermost meiocytes and surrounding somatic cells (tapetum) are differentiated from the same precursor archesporial cells, and these cells acquire distinct cell identities after specification. However, the underlying mechanism regulating meiocyte identity is elusive. Here we demonstrate a conserved surveillance mechanism governed by Arabidopsis zinc-finger proteins C3H14 and C3H15, which redundantly regulate mRNA homoeostasis to ensure meiocyte identity. The meiocytes of Atc3h14 Atc3h15 display meiotic arrest accompanied by ectopic accumulation of mRNAs essential for archesporial cell differentiation and tapetum development. These meiocytes ultimately undergo reactive oxygen species bursts and programmed cell death in synchrony with the tapetum. Moreover, C3H14/C3H15 interacts with processing-body proteins and the CCR4-NOT deadenylase complex, and is required for eliminating unwanted transcripts. Consistently, CRISPR-Cas9-induced mutations in AtC3H14/15 paralogues in soybean and rice caused similar defects in meiocyte identity, indicating that the regulation of meiocyte identity by post-transcriptional RNA elimination is conserved in flowering plants.

Identifiers

PMID42711403

DOI10.1038/s41467-019-09234-6

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.