Stereosequence- and topology-controlled synthesis of cyclic polyesters.

Ziyu Huo, Xiaoyu Xie, Huida Duan, Yifan Cheng, Rong Tong

Abstract read

In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Ziyu HuoDepartment of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

Xiaoyu XieDepartment of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

Huida DuanDepartment of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

Yifan ChengDepartment of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.ORCID http://orcid.org/0000-0003-2312-093X

Rong TongDepartment of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. rtong@vt.edu.ORCID http://orcid.org/0000-0002-2034-9272

Funding

National Science Foundation (NSF) CHE-240469

6 · The paper itself

Abstract

Stereoselective control in cyclic polyester synthesis, particularly stereosequence-defined cyclic copolyesters, has not yet been achieved in a single catalytic platform. Achieving this combination is challenging because stereocontrol requires precise chain-end discrimination, whereas ring-expansion growth that generates cyclic topology can be readily perturbed in monomer mixtures. Herein, we report lanthanum catalysts for isoselective ring-expansion polymerization of amino acid-derived O-carboxyanhydrides, affording high-molecular-weight (>100 kDa) cyclic stereoblock poly(α-hydroxy acids) with diverse pendant functional groups, narrow molecular-weight distributions (Ɖ < 1.1), and high isotacticities (P

Identifiers

PMID42711335

DOI10.1038/s41467-026-77071-5

PMCPMC13554224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.