Evidence map›Paper›PMID 42711302›Full record

ArticleNature communications2026

APOBEC3-driven attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestor.

Rebecca P Sumner, Lucy Eke, Bruno Hernáez, Alasdair J M Hood, Telma Sancheira Freitas, Hannah Ashby, Ailish Ellis, Marine Petit, Sian Lant, Isobel Stokes and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Rebecca P SumnerDepartment of Microbial Sciences, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0003-0735-8649
Lucy EkeDepartment of Microbial Sciences, University of Surrey, Guildford, UK.
Bruno HernáezCentro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID http://orcid.org/0000-0002-4351-0102
Alasdair J M HoodDepartment of Microbial Sciences, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0003-1110-7957
Telma Sancheira FreitasDepartment of Microbial Sciences, University of Surrey, Guildford, UK.
Hannah AshbyDepartment of Microbial Sciences, University of Surrey, Guildford, UK.
Ailish EllisDepartment of Microbial Sciences, University of Surrey, Guildford, UK.ORCID http://orcid.org/0009-0008-4601-6426
Marine PetitDepartment of Microbial Sciences, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0001-7427-7203
Sian LantDepartment of Microbial Sciences, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0001-7764-3520
Isobel StokesDepartment of Microbial Sciences, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-1833-2754
Preetam ParijaDepartment of Microbial Sciences, University of Surrey, Guildford, UK.
Isabel AlonsoCentro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID http://orcid.org/0000-0002-6304-4938
Francisco J Alvarez-de MirandaCentro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Alazne R UnanueCentro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID http://orcid.org/0009-0006-6927-9996
Kevin MaringerThe Pirbright Institute, Pirbright, UK.ORCID http://orcid.org/0000-0003-0977-8807
Isabelle DietrichThe Pirbright Institute, Pirbright, UK.
Bryan CharlestonThe Pirbright Institute, Pirbright, UK.
Geoffrey L SmithSir William Dunn School of Pathology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3730-9955
David O UlaetoCBR Division, Defence Science and Technology Laboratory, Salisbury, UK.ORCID http://orcid.org/0000-0002-7493-3159
Antonio AlcamíCentro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID http://orcid.org/0000-0002-3333-6016
Carlos Maluquer de MotesDepartment of Microbial Sciences, University of Surrey, Guildford, UK. c.maluquerdemotes@surrey.ac.uk.ORCID http://orcid.org/0000-0003-4712-4601

Funding

"la Caixa" Foundation (Caixa Foundation) HR23-00558RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BBS/E/PI/23NB0003RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BBS/E/PI/23NB0004RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V015265/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X0011356/1Royal Society RGS\R2\252220
6 · The paper itself

Abstract

Monkeypox virus (MPXV) is a zoonotic virus endemic to Africa that has recently re-emerged, becoming the first orthopoxvirus with sustained human-to-human transmission since smallpox eradication. The 2022 global epidemic of MPXV was caused by Clade IIb virus (lineage B.1) that derived from the lineage A endemic to West Africa through APOBEC3 microevolution

Indexed as

Cytidine DeaminaseMonkeypox virusMpox, MonkeypoxAnimalsDisease OutbreaksEvolution, MolecularHumansImmunity, InnateInterferon-betaMiceMutationPhylogenyVirulenceVirus ReplicationCytidine DeaminaseInterferon-beta

Identifiers

PMID42711302
PMCPMC13554265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.