Evidence map›Paper›PMID 42711118›Full record

ArticleeNeuro2026

An Allometric Approach to Fine-Mapping Subcortical Volume Alterations in RASopathies.

Chloe A McGhee-Deakin, Odeya Russo, Julia R Plank, Tamar Green

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chloe A McGhee-DeakinDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford 94305 camcghee@stanford.edu.ORCID 0000-0002-6357-9721
Odeya RussoDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford 94305.
Julia R PlankDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford 94305.
Tamar GreenDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford 94305.ORCID 0000-0001-5661-8297

Funding

Gaining insights: the effects of the RMK gain-of-function mutations on brain development and neurodevelopmental disordersR01HD108684 · NICHD · STANFORD UNIVERSITY · PI Tamar Green · 2022 to 2026
$3.0M
NICHD NIH HHS R01 HD108684
6 · The paper itself

Abstract

Structural neuroimaging in youth with RASopathies has shown alterations in total brain volume (TBV) and subcortical structures. However, whether these subcortical differences scale proportionately with TBV or follow nonlinear allometric relationships remains unclear, limiting accurate interpretation of neuroanatomical findings and their relevance to cognition. Using an allometric framework, this study aimed to determine whether (1) subcortical volumes exhibit deviations from normative scaling in RASopathies and (2) methods used to account for TBV influence the detection of subcortical volume alterations. We examined youth with RASopathies (

Indexed as

BrainLEOPARD SyndromeNeurofibromatosis 1Noonan SyndromeAdolescentChildFemaleHumansMagnetic Resonance ImagingMaleNeurofibromin 1Organ SizeProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-rafSOS1 ProteinNeurofibromin 1NF1 protein, humanProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-rafPTPN11 protein, humanRaf1 protein, humanSOS1 ProteinSOS1 protein, humanallometrymorphometryneurofibromatosis type 1Noonan syndromeNoonan syndrome with multiple lentiginesRASopathies

Identifiers

PMID42711118
PMCPMC13592736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.