Evidence map›Paper›PMID 42711067›Full record

ArticleJournal of neuroendocrinology2026

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice.

Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S Halls, James A Frank, Martin J Kelly, Kevin T O'Byrne

Abstract read
In one paragraph

Article in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jian QiuDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-4988-8587
Yanyan LinDepartment of Women and Children's Health, School of Life Course and Population Sciences, King's College London, Guy's Campus, London, UK.ORCID https://orcid.org/0009-0004-3472-6990
Emily BartramDepartment of Women and Children's Health, School of Life Course and Population Sciences, King's College London, Guy's Campus, London, UK.ORCID https://orcid.org/0009-0000-9435-072X
Janelle M TobiasDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0003-1700-2646
Antonio MuñozOregon Health & Science University, Vollum Institute, Portland, Oregon, USA.ORCID https://orcid.org/0000-0001-8340-8842
Xiao Feng LiDepartment of Women and Children's Health, School of Life Course and Population Sciences, King's College London, Guy's Campus, London, UK.ORCID https://orcid.org/0000-0001-9974-1340
Victoria S HallsMedicinal Chemistry Core Facility, Oregon Health & Science University, Portland, Oregon, USA.
James A FrankDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0001-6705-2540
Martin J KellyDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-8633-2510
Kevin T O'ByrneDepartment of Women and Children's Health, School of Life Course and Population Sciences, King's College London, Guy's Campus, London, UK.ORCID https://orcid.org/0000-0002-2548-4182

Funding

Biotechnology and Biological Sciences Research Council BB/005913/1NIH Grant DK068098OHSU Medicinal Chemistry Core SCR_019048OHSU School of Medicine Faculty Innovation Fund Pilot Program
6 · The paper itself

Abstract

Pulsatile gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1

Indexed as

Arcuate Nucleus of HypothalamusKisspeptinsLuteinizing HormoneNerve NetNeuronsPeptide FragmentsAnimalsFemaleHEK293 CellsHumansMiceMice, Inbred C57BLReceptors, Neurokinin-3Substance PKisspeptinsLuteinizing HormonePeptide FragmentsReceptors, Neurokinin-3senktideSubstance Pazo‐senktidekisspeptinLHpeptidephotoswitchable

Identifiers

PMID42711067
PMCPMC13553209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.