Evidence map›Paper›PMID 42710913›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Local endothelin-1 receptor type A antagonism improves cutaneous microvascular function in women with a history of gestational diabetes mellitus.

Grace S Maurer, Kara M Whitaker, Diana I Jalal, Anna E Stanhewicz

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Grace S MaurerDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-6952-5097
Kara M WhitakerDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-2343-4162
Diana I JalalDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-1975-8650
Anna E StanhewiczDepartment of Health, Sport, and Human Physiology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-3941-3879

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
The role of oxidative stress in reduced microvascular function after gestational diabetesR01HL169201 · NHLBI · UNIVERSITY OF IOWA · PI ANNA STANHEWICZ · 2023 to 2026
$2.4M
Endothelin-1 signaling in microvascular responses to insulin and the role of physical activity and sedentary behavior in women with a history of gestational diabetes mellitusF31HL177925 · NHLBI · UNIVERSITY OF IOWA · PI Grace Susan Maurer · 2025 to 2026
$77k
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002537HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL177925HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL169201NCATS NIH HHS UL1 TR002537NHLBI NIH HHS F31 HL177925NHLBI NIH HHS R01 HL169201
6 · The paper itself

Abstract

Women with a history of gestational diabetes mellitus (GDM) are at a greater risk of developing cardiovascular disease (CVD) compared with women who had an uncomplicated pregnancy. Microvascular endothelial dysfunction, mediated in part by reduced nitric oxide (NO)-dependent mechanisms, persists after GDM and contributes to vascular disease progression. Endothelin-1 (ET-1), a potent vasoconstrictor, contributes to vascular dysfunction in diabetes and may similarly contribute to vascular dysfunction after GDM. We hypothesized that local ET-1 receptor type A (ET

Indexed as

Diabetes, GestationalEndothelin A Receptor AntagonistsMicrocirculationMicrovesselsPeptides, CyclicReceptor, Endothelin ASkinVasodilationAdultCase-Control StudiesEndothelin-1Endothelium, VascularFemaleHumansMicrodialysisNitric Oxidecyclo(Trp-Asp-Pro-Val-Leu)EDNRA protein, humanEndothelin-1Endothelin A Receptor AntagonistsNitric OxidePeptides, CyclicReceptor, Endothelin Aendothelial dysfunctionendothelin-1gestational diabetesmicrovascular

Identifiers

PMID42710913
PMCPMC13617649

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.