Evidence map›Paper›PMID 42710853›Full record

ArticleJornal de pediatria2026

Circumcision and continuous antibiotic prophylaxis in preventing recurrent febrile urinary tract infection in boys with high-grade vesicoureteral reflux.

Xiaoyu Tang, Liwen Sun, Xiangxiang Chen, Hui Wang, Jinxia Wang, Yan Chen, Yulin Kang, Yue Zhang, Yiqing Lyu, Fang Chen and 2 more

Abstract read
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In one paragraph

Article in Jornal de pediatria, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Xiaoyu TangDepartment of Urology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Liwen SunDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiangxiang ChenDepartment of Urology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Hui WangDepartment of Urology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jinxia WangClinical Research Unit, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yan ChenDepartment of Urology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yulin KangDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yue ZhangSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Yiqing LyuDepartment of Urology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Fang ChenDepartment of Urology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Lijun ZhouDepartment of Urology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yichen HuangDepartment of Urology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: drhuangyichen@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effectiveness of circumcision and continuous antibiotic prophylaxis (CAP) in preventing febrile urinary tract infection (fUTI) in boys with high-grade primary vesicoureteral reflux (VUR).

methodsThis retrospective cohort included 114 boys younger than 5 years diagnosed with grades III-V primary VUR between June 2019 and June 2022. Patients were managed with observation (n = 14), CAP alone (n = 23), circumcision alone (n = 38), and combined CAP and circumcision (n = 39). The follow-up duration was 2 years. The incidence of fUTIs in each group was recorded, and associations between conservative management strategies and fUTI recurrence were analyzed.

results15 (13.2%) children experienced recurrent fUTIs. Recurrence rates were 42.9% in the observation group, 30.4% in the CAP group, 5.3% in the circumcision group, and 0% in the CAP+ circumcision group. Circumcision-containing groups (circumcision alone and CAP + circumcision) had significantly lower recurrence rates than non-circumcision groups (observation and CAP alone) (p < 0.05). Multivariable Firth-penalized logistic regression confirmed circumcision as an independent protective factor against fUTI recurrence (aOR = 0.09, 95% CI: 0.01-0.98, p = 0.042), while CAP alone showed no significant protective effect (aOR = 0.45, 95% CI: 0.06-3.21, p = 0.421).

conclusionCircumcision significantly reduced fUTI recurrence in boys with grade III-V primary VUR and may represent an important component of conservative management in this high-risk population, whereas the added value of CAP remains uncertain.

Indexed as

ChildrenCircumcisionContinuous antibiotic prophylaxisFebrile urinary tract infectionVesicoureteral reflux

Identifiers

PMID42710853
PMCPMC13626786

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