Evidence map›Paper›PMID 42710678›Full record

ArticleThe Journal of biological chemistry2026

Nitric oxide dependent metabolic and genetic dysregulation in metastatic triple-negative breast cancer.

Jennifer N Daw, Pricila K Moly, Su Chung, Sarah Young, Nhi Van, Sara Centuori, David G Besselsen, Nathan Ellis, Ronald L Heimark, William R Montfort

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer N DawUniversity of Arizona Cancer Center, Tucson, Arizona, USA; CBIO Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA.
Pricila K MolyDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Su ChungDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Sarah YoungDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Nhi VanDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Sara CentuoriUniversity of Arizona Cancer Center, Tucson, Arizona, USA.
David G BesselsenUniversity Animal Care, University of Arizona, Tucson, Arizona, USA.
Nathan EllisUniversity of Arizona Cancer Center, Tucson, Arizona, USA; CBIO Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA.
Ronald L HeimarkUniversity of Arizona Cancer Center, Tucson, Arizona, USA; CBIO Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA; Department of Surgery, University of Arizona, Tucson, Arizona, USA.
William R MontfortUniversity of Arizona Cancer Center, Tucson, Arizona, USA; CBIO Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA; Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA. Electronic address: montfort@arizona.edu.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Uranium as an Environmental Risk Factor for Cancer Among the NavajoU54CA143924 · NCI · UNIVERSITY OF ARIZONA · PI Gloria D. Coronado · 2009 to 2026
$26.7M
PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
Nitric Oxide Signaling in Health and DiseaseR01GM117357 · NIGMS · UNIVERSITY OF ARIZONA · PI MONTFORT, WILLIAM R. · 2015 to 2018
$1.4M
Nitric oxide inhibits Iron(II)2-Oxogluterate dependent demethylases to regulate DNA and mRNA methylationR01GM155946 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI THOMAS, DOUGLAS D. · 2024 to 2025
$901k
NCI NIH HHS P30 CA023074NCI NIH HHS U54 CA143924NHLBI NIH HHS T32 HL007249NIGMS NIH HHS R01 GM117357NIGMS NIH HHS R01 GM155946
6 · The paper itself

Abstract

Chronic inflammation drives many diseases, including cancer, where inflammation is associated with metastasis, the cause of death in 90% of cancer fatalities. Tumor inflammation drives inducible nitric oxide synthase (NOS2) and cyclooxygenase 2 (COX2) expression, each of which is associated with poor outcomes in cancer. Here, we knocked out the NOS2 gene in the murine triple-negative breast cancer allograft tumor model 4T1 and examined metastatic spread from primary mammary tumors to lung in BALB/c mice with intact immune systems. Remarkably, while the parental 4T1 tumors were highly metastatic, metastasis from 4T1 NOS2

Indexed as

epigeneticsimmunosuppressioninflammationmetabolismnitric oxide

Identifiers

PMID42710678
PMCPMC13659492

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.