Monomeric C-reactive protein potentiates microglia-mediated neuroinflammation in Alzheimer's disease via the PLC-PKC-MAPK-NF-κB pathway.

Jie Zhang, Yiyi Zhu, Qishan Zhang, Yuting Dai, Hang Liu, Jingming Shi, Yanghua Jiang, Qian Chen

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Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Jie ZhangThe Key Laboratory for High Altitude Brain Injury and Repair, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi Province, China.

Yiyi ZhuThe Key Laboratory for High Altitude Brain Injury and Repair, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi Province, China.

Qishan ZhangDepartment of Neurology, The First People's Hospital of Chenzhou City, Chenzhou, Hunan Province, China.

Yuting DaiThe Key Laboratory for High Altitude Brain Injury and Repair, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi Province, China.

Hang LiuThe Key Laboratory for High Altitude Brain Injury and Repair, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi Province, China.

Jingming ShiThe Key Laboratory for High Altitude Brain Injury and Repair, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi Province, China. Electronic address: shijingming5272@126.com.

Yanghua JiangLaboratory Medical Center of the First People's Hospital of Chenzhou City, Chenzhou, Hunan Province, China. Electronic address: jiangyanghua1225@126.com.

Qian ChenThe Key Laboratory for High Altitude Brain Injury and Repair, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi Province, China. Electronic address: chenqianxj666@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation is a major contributor to the pathogenesis of Alzheimer's disease (AD). Although elevated serum C-reactive protein (CRP) is associated with increased AD risk, the specific conformational forms of CRP operative in the brain and their underlying mechanisms remain unclear. Here, we combined human brain transcriptomic analysis, APP/PS1 mice studies, and functional assays in BV2 cells and primary microglia to elucidate the roles of Monomeric C-reactive protein (mCRP) in AD-related neuroinflammation. CRP was significantly upregulated in the brains of AD patients and in the hippocampus of APP/PS1 mice, where it extensively colocalized with activated microglia. mCRP directly induced M1 proinflammatory microglial polarization and synergistically enhanced neuroinflammation with amyloid-β

Indexed as

Alzheimer's disease(AD)microgliamonomeric C-reactive protein (mCRP)neuroinflammationPLC/PKC/MAPK/NF-κB signaling pathway

Identifiers

PMID42710667

DOI10.1016/j.jbc.2026.113527

PMCPMC13671087

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.