Evidence map›Paper›PMID 42710366›Full record

ArticleNeuroImage. Clinical2026

Functional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.

Jinlong Liu, Veronika Purrer, Jonas Krauss, Valeri Borger, Markus Essler, Alexander Radbruch, Ullrich Wüllner, Neeraj Upadhyay, Henning Boecker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinlong LiuUniversity of Bonn, University Hospital Bonn, Clinical Functional Imaging Group, Department of Nuclear Medicine, Venusberg-Campus 1, 53127, Bonn, Germany.
Veronika PurrerGerman Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany; University of Bonn, University Hospital Bonn, Clinic for Parkinson's Disease, Sleep Disorders, and Movement Disorders, Venusberg-Campus 1, 53127, Bonn, Germany.
Jonas KraussUniversity of Bonn, University Hospital Bonn, Clinical Functional Imaging Group, Department of Nuclear Medicine, Venusberg-Campus 1, 53127, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany; University of Bonn, University Hospital Bonn, Clinic for Parkinson's Disease, Sleep Disorders, and Movement Disorders, Venusberg-Campus 1, 53127, Bonn, Germany.
Valeri BorgerUniversity of Bonn, University Hospital Bonn, Department of Neurosurgery, Venusberg-Campus 1, 53127, Bonn, Germany.
Markus EsslerUniversity of Bonn, University Hospital Bonn, Department of Nuclear Medicine, Venusberg-Campus 1, 53127, Bonn, Germany.
Alexander RadbruchGerman Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany; University of Bonn, University Hospital Bonn, Department of Neuroradiology, Venusberg-Campus 1, 53127, Bonn, Germany.
Ullrich WüllnerGerman Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany; University of Bonn, University Hospital Bonn, Clinic for Parkinson's Disease, Sleep Disorders, and Movement Disorders, Venusberg-Campus 1, 53127, Bonn, Germany.
Neeraj UpadhyayUniversity of Bonn, University Hospital Bonn, Clinical Functional Imaging Group, Department of Nuclear Medicine, Venusberg-Campus 1, 53127, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany.
Henning BoeckerUniversity of Bonn, University Hospital Bonn, Clinical Functional Imaging Group, Department of Nuclear Medicine, Venusberg-Campus 1, 53127, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, 53127, Bonn, Germany. Electronic address: Henning.Boecker@ukbonn.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMagnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy alleviates tremor in tremor-dominant Parkinson's disease (TD-PD). However, its effects on the functional network topology remain unclear.

methodsTwenty-one TD-PD patients underwent unilateral MRgFUS thalamotomy and clinical and MRI assessments. For the overall cohort, graph theory analysis was employed to examine differences in small-world properties and modular structure between baseline and 6 months after MRgFUS. Changes in topological properties were assessed using paired t-tests or Wilcoxon tests, and their associations with clinical improvement. Additionally, subgroup analyses were performed on responder (n = 10) and relapser (n = 9) data.

resultsTremor scores decreased significantly after MRgFUS contralateral to the lesioned thalamus. Significant increases were observed in small-worldness and normalized clustering coefficient after MRgFUS. Inter-modular connectivity showed trend-level enhancement between cortical-basal ganglia and thalamic modules, and between cerebellar and temporal-hippocampal modules. In responder, significant increases were observed in small-worldness, normalized clustering coefficient, and global efficiency, whereas characteristic path length showed a significant decrease. Changes in global efficiency and characteristic path length were significantly correlated with clinical improvement.

conclusionMRgFUS thalamotomy for TD-PD induced partial reorganization of small-world properties, indicating a shift toward a more integrated network topology, especially in responder. Changes correlated with tremor reduction and improved functional disability, highlighting that effective treatment impacts on global network integration.

Indexed as

Brain networksGraph theory analysisMRgFUSParkinson's diseaseSmall-worldness

Identifiers

PMID42710366
PMCPMC13573704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.