ArticleClinics (Sao Paulo, Brazil)2026
Population-specific patterns of IgE sensitization in Northwest China.
Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundImmunoglobulin E (IgE)-mediated allergic diseases are a major and growing global health burden, with sensitization patterns varying by region and population. Comprehensive data from Northwest China remain limited. This study aimed to characterize population-specific IgE sensitization profiles in this region and explore their associations with sex and age.
methodsWe retrospectively analyzed 13,123 patients with allergic diseases at a large tertiary center in Northwest China from January 2017 to June 2024. Demographic data, clinical diagnoses, and serum allergen-specific IgE (sIgE) levels measured by ImmunoCAP were collected. Sensitization was defined as sIgE ≥ 0.35 kUA/L. Statistical analyses included Chi-Square tests and Spearman correlation.
resultsThe cohort included 5,928 males (45.18%) and 7,195 females (54.82%), with children under 5-years constituting the largest subgroup (23.04%). Males had significantly higher sensitization rates than females for both food allergens (p < 0.001) and inhalant allergens (p < 0.001). Food allergen sensitization peaked in children under 10-years (6.69%-8.22%), while inhalant allergen sensitization peaked in the 10-20 years age group (10.92%). Among tested allergens, peanut induced the highest reactivity level, and egg white showed the highest disease-specific sensitization rate in asthma patients (19.57%).
conclusionsThis study reveals distinct, population-specific IgE sensitization patterns in Northwest China, significantly influenced by sex and age. Findings highlight a higher sensitization burden in males and an age-dependent shift from food to inhalant allergen predominance. These insights support a stratified, precision-based approach to allergy diagnosis and management tailored to regional allergen exposures.
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