ArticleClinical and experimental dental research2026
Collagen Substitutes in Oral Soft Tissue Augmentation: An In Vitro-Ex Vivo Study on Expansion and Elasticity.
Article in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Collagen Substitutes in Oral Soft Tissue Augmentation: An In Vitro-Ex Vivo Study on Expansion and Elasticity.Clinical and experimental dental research · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveThis study aimed to evaluate the hydration-induced volumetric expansion and elasticity of collagen-based soft tissue substitutes following exposure to blood using three-dimensional (3D) analysis and high-frequency ultrasonography (HFUS). MATERIALS AND
methodsSeven commercially available collagen matrices were analyzed: Fibro-Gide (6 mm and 3 mm), Mucogain (5 mm and 3 mm), Volumax, Collagen Graft II, and Mucograft. The investigation consisted of two experimental phases. In the in vitro phase, samples were immersed in stabilized porcine blood to assess absorption index (AI), 3D volumetric changes, and ultrasonographic (HFUS) parameters, including density and elasticity. In the ex vivo phase, matrices were placed beneath envelope flaps in porcine maxillae, with optical 3D scanning performed before and after blood saturation. Statistical analysis included generalized estimating equations for repeated measures and nonparametric testing, with significance set at α = 0.05.
resultsVolume stable matrices exhibited significantly greater absorption and volumetric expansion compared to non-stable matrices. Fibro-Gide 6 mm demonstrated the highest absorption index (17.0 ± 0.6 mg) and volumetric increase (268.4 ± 54.8 mm
conclusionsVolume-stable collagen matrices show pronounced fluid uptake and expansion. Clinically, this effect should be considered, as excessive swelling may increase flap tension and compromise wound stability, necessitating careful trimming and adequate flap release.
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