Evidence map›Paper›PMID 42709801›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A host-encoded prophage targets a Candidate Phyla Radiation bacterium and shapes episymbiotic interactions.

Ajay Kumar, Nusrat Nahar, Deepak Chouhan, Jeffrey S McLean, Batbileg Bor, Pu-Ting Dong, Xuesong He

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ajay KumarDepartment of Microbiology, American Dental Association Forsyth Institute, Somerville, MA 02143.ORCID 0009-0002-9757-3085
Nusrat NaharDepartment of Microbiology, American Dental Association Forsyth Institute, Somerville, MA 02143.ORCID 0009-0005-1898-5121
Deepak ChouhanDepartment of Microbiology, American Dental Association Forsyth Institute, Somerville, MA 02143.
Jeffrey S McLeanDepartment of Periodontics, University of Washington, Seattle, WA 98195.ORCID 0000-0001-9934-5137
Batbileg BorDepartment of Microbiology, American Dental Association Forsyth Institute, Somerville, MA 02143.ORCID 0000-0002-1797-1730
Pu-Ting DongDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794.
Xuesong HeDepartment of Microbiology, American Dental Association Forsyth Institute, Somerville, MA 02143.ORCID 0000-0002-3333-9188

Funding

Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Forsyth Training in Oral Health ResearchT90DE026110 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI THOMAS Elliott VAN DYKE · 2017 to 2026
$3.0M
Impact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory DiseasesR01DE031274 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Batbileg Bor · 2022 to 2026
$2.5M
Host tRNA-derived small RNAs (tsRNAs) mediate interactions between host and oral microbesR01DE030943 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Xuesong He · 2022 to 2026
$2.4M
HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) R01DE023810HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) R01DE031274HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) T90DE026110NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE030943NIDCR NIH HHS R01 DE031274NIDCR NIH HHS T90 DE026110
6 · The paper itself

Abstract

The Patescibacteriota, also known as the Candidate Phyla Radiation (CPR), represent a large lineage of ultrasmall bacteria with highly reduced genomes and obligate dependence on bacterial hosts. Although genomic analyses have revealed CRISPR-Cas and restriction-modification systems in many CPR genomes, no cognate bacteriophages (phages) have been isolated, leaving CPR-phage interactions unexplored.

Indexed as

ProphagesSymbiosisBacteriophagesHumansLysogenybacteriophageCandidate Phyla Radiationepisymbiosisoral microbiomePatescibacteria

Identifiers

PMID42709801
PMCPMC13578794

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.