Evidence map›Paper›PMID 42709399›Full record

ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2026

Assessment of the effectiveness of intraosseous anaesthesia during restorative procedures on teeth affected by molar incisor hypomineralisation in children.

K Muzinic, J P Vucak, T Skrinjaric, J Stojanovic, T Galic, D Glavina, H Juric, K Gorseta

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Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07457450 (Evaluating the Effectiveness of Intraosseous Anesthesia During Restorative Procedures on Teeth Affected by Molar Incisive Hypomineralization in Children), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07457450 naactive not recruitingnot on this map

Evaluating the Effectiveness of Intraosseous Anesthesia During Restorative Procedures on Teeth Affected by Molar Incisive Hypomineralization in Children

TypeinterventionalSponsorUniversity of ZagrebRan2023 to 2026Enrolled50ConditionsMolar Incisor HypomineralisationArmsIntraosseous anesthesia., Local infiltration anesthesia
3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

K MuzinicDental Polyclinic Split, Split, Croatia.
J P VucakDental Polyclinic Zagreb, Zagreb, Croatia.
T SkrinjaricSchool of Dental Medicine, Dept. of Pediatric and Preventive Dentistry, University of Zagreb, Zagreb, Croatia.
J StojanovicSchool of Dental Medicine, Dept. of Pediatric and Preventive Dentistry, University of Zagreb, Zagreb, Croatia.
T GalicStudy of Dental Medicine, University of Split, School of Medicine, Split, Croatia.
D GlavinaSchool of Dental Medicine, Dept. of Pediatric and Preventive Dentistry, University of Zagreb, Zagreb, Croatia.
H JuricSchool of Dental Medicine, Dept. of Pediatric and Preventive Dentistry, University of Zagreb, Zagreb, Croatia.
K GorsetaSchool of Dental Medicine, Dept. of Pediatric and Preventive Dentistry, University of Zagreb, Zagreb, Croatia. gorseta@sfzg.unizg.hr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMolar incisor hypomineralisation (MIH) is an enamel defect that impacts at least one first permanent molar, frequently involving the incisors. Managing MIH-affected teeth is challenging due to inflammation, sensitivity, rapid caries development and difficulty achieving anaesthesia. Local anaesthesia, linked to pain, is a key factor in fear and discomfort in children. The objective of this study was to evaluate and compare the effectiveness of intraosseous (IO) and intraligamentary anaesthesia in providing analgesia during restorative procedures for MIH-affected molars in children aged 6 to 14 years.

methodsIn a split-mouth study, 25 healthy patients (aged 6-14 years) with confirmed MIH on the lower first permanent molars participated. Each child underwent two restorative procedures: one with intraligamentary anaesthesia on the first visit, and second with intraosseous anaesthesia using the QuickSleeper™ computerised system on the subsequent visit. The teeth were restored with glass ionomer fillings in both sessions. Parameters evaluated included onset time, pain during administration, repeat anaesthesia needs, anaesthetic efficacy, heart rate and postoperative complications. Statistical analysis was performed.

resultsIO anaesthesia provided significantly faster onset and lower pain during administration compared to intraligamentary anaesthesia. Heart rate was significantly lower during restorative procedures with IO anaesthesia. Intraligamentary anaesthesia achieved profound analgesia in 24% of MIH-affected teeth, whilst IO anaesthesia achieved profound analgesia in 80% of cases.

conclusionIO anaesthesia demonstrated superior efficacy and less pain compared to intraligamentary anaesthesia for restorative procedures on MIH-affected first permanent mandibular molars in children, with faster onset and higher success in achieving profound anaesthesia.

trial registrationClinicalTrials.gov Identifier: NCT07457450; February 11th, 2026, retrospectively registered.

Indexed as

Anaesthesia, localFirst permanent molarInjections, intraosseousPaediatric dentistryTooth abnormalities

Identifiers

PMID42709399

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