Evidence map›Paper›PMID 42709314›Full record

ArticleOdontology2026

Efficacy of injectable platelet-rich fibrin with guided tissue regeneration and bone grafting in the management of alveolar bone defects in patients with chronic periodontitis and baseline vitamin D deficiency.

Jie Huang, Qian-Qian Chen, Yi Zeng, Kun Yang, Li Gao, Quan-Min He, Fu-Hua Yan, Song Ge

Abstract read
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Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jie Huang *Department of Periodontology, School and Hospital of Stomatology, Zunyi Medical University, No. 143, Dalian Road, Huichuan District, Zunyi, 563000, Guizhou, China.
Qian-Qian Chen *Xuzhou Medical University Affiliated Stomatological Hospital, Xuzhou, 221000, Jiangsu Province, China.
Yi ZengDepartment of Periodontology, School and Hospital of Stomatology, Zunyi Medical University, No. 143, Dalian Road, Huichuan District, Zunyi, 563000, Guizhou, China.
Kun YangDepartment of Periodontology, School and Hospital of Stomatology, Zunyi Medical University, No. 143, Dalian Road, Huichuan District, Zunyi, 563000, Guizhou, China.
Li GaoDepartment of Periodontology, School and Hospital of Stomatology, Zunyi Medical University, No. 143, Dalian Road, Huichuan District, Zunyi, 563000, Guizhou, China.
Quan-Min HeDepartment of Periodontology, School and Hospital of Stomatology, Zunyi Medical University, No. 143, Dalian Road, Huichuan District, Zunyi, 563000, Guizhou, China.
Fu-Hua YanDepartment of Periodontology, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, 210008, China.
Song GeDepartment of Periodontology, School and Hospital of Stomatology, Zunyi Medical University, No. 143, Dalian Road, Huichuan District, Zunyi, 563000, Guizhou, China. gesong86@126.com.

Funding

Hospital-level New Technology Project: Application of Viscous Bone Blocks in Oral Tissue Regeneration Project No. 2024-10-11National Natural Science Foundation of China: Effects and Mechanisms of Porphyromonas gingivalis Outer Membrane Vesicles in Inducing Pyroptosis of Vascular Endothelial and Smooth Muscle Cells via NLRP3 Inflammasome Pathway Grant No.82560193The "942" Plan Project for Tiered Development of Key Clinical Specialties The "942" Plan Project for Tiered Development of Key Clinical SpecialtiesThe Guizhou Provincial Funding Program for National Key Clinical Specialty Capacity Building 2023
6 · The paper itself

Abstract

The aim of this study was to assess the clinical efficacy of injectable platelet-rich fibrin (i-PRF) combined with guided tissue regeneration (GTR) and bone grafting for site-specific reconstruction of alveolar bone defects in patients with chronic periodontitis and vitamin D deficiency. A total of 34 periodontal surgical sites in patients diagnosed with chronic periodontitis and baseline vitamin D deficiency defined as serum 25-hydroxyvitamin D₃ (25-[OH]D₃) levels < 20 µg/L were included. Sites were randomly assigned to either a study or control group using a random number table. All patients received basic periodontal therapy and standardized vitamin D supplementation. Upon correction of serum 25-[OH]D₃ levels to ≥ 30 µg/L, sites in the study group (n = 17) underwent GTR using sticky bone prepared from i-PRF combined with deproteinized bovine bone mineral (Bio‑Oss

Indexed as

Bone graftingChronic periodontitisGuided tissue regenerationPlatelet-rich fibrinSticky boneVitamin D

Identifiers

PMID42709314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.