Evidence map›Paper›PMID 42709310›Full record

ArticleJournal of natural medicines2026

Lusitropic effect of Aurantii Fructus Immaturus extract on isolated mouse ventricular myocardium.

Maika Seki, Yuna Shiota, Ayaka Konno, Kouharu Otsuki, Takashi Kikuchi, Shogo Hamaguchi, Wei Li, Iyuki Namekata, Hikaru Tanaka

Abstract read
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Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maika SekiDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan.
Yuna ShiotaDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan.
Ayaka KonnoDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan.
Kouharu OtsukiDepartment of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan.
Takashi KikuchiDepartment of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan.
Shogo HamaguchiDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan.
Wei LiDepartment of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan.
Iyuki NamekataDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan. iyuki@phar.toho-u.ac.jp.
Hikaru TanakaDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, 274-8510, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired myocardial relaxation is a key feature of diastolic dysfunction-associated heart failure, including heart failure with preserved ejection fraction (HFpEF), and the development of agents with lusitropic activity is highly desired. In the present study, we investigated the direct acute effects of the methanolic extract from Aurantii Fructus Immaturus (Kijitsu) on myocardial relaxation and explored its active constituents and underlying mechanisms. Using isolated mouse right ventricular myocardial preparations, relaxation was evaluated by measuring the 90% relaxation time (RT

Indexed as

Aurantii Fructus ImmaturusFlavonoidsMyocardial relaxationSarco/endoplasmic reticulum Ca2+-ATPase

Identifiers

PMID42709310

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.