Evidence map›Paper›PMID 42709308›Full record

ArticleJournal of natural medicines2026

Chemical constituents of Guarea glabra: a new alkaloid, a new dihydro-α-pyrone, and antitrypanosomal pimarane-type diterpenes.

Takehiro Nishimura, Yuto Yamauchi, Naoko Yoshida, Ulises G Castillo, Karla Alas, Gabriel Cerén, Toshihiro Mita, Junko Nakajima-Shimada, Marvin J Núñez, Haruhisa Kikuchi

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takehiro NishimuraDivision of Natural Medicines, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. takehiro-nishi@keio.jp.ORCID http://orcid.org/0000-0002-6600-9193
Yuto YamauchiDivision of Natural Medicines, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Naoko YoshidaDepartment of Tropical Medicine and Parasitology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Ulises G CastilloLaboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Av. de Mártires y Héroes del 30 de Julio, 1101, San Salvador, El Salvador.ORCID http://orcid.org/0000-0002-2159-7008
Karla AlasMinisterio de Educación, Ciencia y Tecnología, San Salvador Centro, 1101, San Salvador, El Salvador.
Gabriel CerénHerbario ITIC, Escuela de Biología, Facultad de Ciencias Naturales y Matemática, Universidad de El Salvador, Final Av. de Mártires y Héroes del 30 de Julio, San Salvador Centro, 1101, San Salvador, El Salvador.ORCID http://orcid.org/0000-0003-1234-1374
Toshihiro MitaDepartment of Tropical Medicine and Parasitology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Junko Nakajima-ShimadaGraduate School of Health Science, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8514, Japan.
Marvin J NúñezLaboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Av. de Mártires y Héroes del 30 de Julio, 1101, San Salvador, El Salvador.ORCID http://orcid.org/0000-0002-0411-6962
Haruhisa KikuchiDivision of Natural Medicines, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. halkiku@keio.jp.ORCID http://orcid.org/0000-0001-6938-0185

Funding

Japan Agency for Medical Research and Developmen 21jm0110016h0005Japan Agency for Medical Research and Development 20jm0110016h0004Japan International Cooperation Agency Japan International Cooperation Agency
6 · The paper itself

Abstract

Chemical investigation of the methanolic extract of Guarea glabra Vahl (Meliaceae) led to the isolation of a new amide alkaloid containing a pyrrolidine moiety (1) and a dihydro-α-pyrone derivative (2), together with two known pimarane-type diterpenes (3, 4). The structures of the new compounds were elucidated using comprehensive spectroscopic analyses, including 1D and 2D NMR experiments. The absolute configuration of 2 was determined by comparing experimental and calculated electronic circular dichroism spectra. Compounds 1-4 demonstrated antitrypanosomal activity against the epimastigote form of Trypanosoma cruzi, with IC

Indexed as

Amide alkaloidAntitrypanosomal activityDihydro-α-pyroneGuarea glabraPimarane-type diterpenes

Identifiers

PMID42709308

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.