ArticleMolecular biology reports2026
Molecular characterization of carbapenem resistance and hypervirulence determinants of Klebsiella pneumoniae circulating in a tertiary hospital in Cyprus.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe emergence of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has become a major global public health concern. Infections caused by CR-Kp strains that also possess hypervirulence traits present significant challenges for clinical management and are associated with increased morbidity and mortality. This study aimed to investigate the prevalence of β-lactamase genes and hypervirulence-associated markers among clinical CR-Kp isolates collected in Cyprus.
methodsA total of 96 K. pneumoniae isolates were investigated. Species-level identification and antimicrobial susceptibility testing were performed using the VITEK-2 system. Carbapenem resistance was assessed using the Modified Hodge test (MHT). Hypermucoviscous phenotype was determined by string test. The presence of carbapenemase genes (bla
resultsAmong isolates, 75 (78.1%) were identified as CR-Kp by the MHT test. Among CR-Kp isolates, 84.0% (63/75) were positive for bla
conclusionsThis is the first report describing CR-Kp isolates with hypervirulence-associated characteristics in Cyprus. The emergence of these convergent strains in the region highlights the need for continuous molecular surveillance and stringent infection control measures in order to avert their future dissemination in the healthcare environment.
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