Evidence map›Paper›PMID 42709233›Full record

Observational studyBrain structure & function2026

Associations between cerebral cortex volume and verbal fluency in community-dwelling adults using magnetic resonance imaging: a cross-sectional observational study.

Kentaro Akazawa, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Teruhide Koyama, Yukina Izumi, Keita Watanabe, Koji Sakai, Yoshinori Marunaka, Akihiro Takada and 2 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Brain structure & function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kentaro AkazawaDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. akazawa@koto.kpu-m.ac.jp.ORCID http://orcid.org/0000-0003-3646-1821
Nagato KuriyamaDepartment of Epidemiology for Community Health and Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Etsuko OzakiDepartment of Epidemiology for Community Health and Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Daisuke MatsuiDepartment of Epidemiology for Community Health and Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Teruhide KoyamaDepartment of Epidemiology for Community Health and Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Yukina IzumiDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Keita WatanabeDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Koji SakaiDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Yoshinori MarunakaMedical Research Institute, Kyoto Industrial Health Association, 67 Kitatuboicho, Nishinokyo, Nakagyo-ku, Kyoto, 604-8472, Japan.
Akihiro TakadaMedical Research Institute, Kyoto Industrial Health Association, 67 Kitatuboicho, Nishinokyo, Nakagyo-ku, Kyoto, 604-8472, Japan.
Toshiki MizunoDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Kei YamadaDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Funding

Grants-in-Aid for Scientific Research for Innovative Areas No. 221S0001Grants-in-Aid for Scientific Research for Priority Areas of Cancer No. 17015018Japan Society for the Promotion of Science (JSPS) KAKENHI Grant No. 16H06277 and 22H04923 [CoBiA]Japan Society for the Promotion of Science (JSPS) KAKENHI Grant, Grant-in-Aid for Scientific Research (C) No. 23390176 and 17K09121
6 · The paper itself

Abstract

With the aging population, identifying the relationship between verbal fluency test (VFT) performance and brain atrophy is crucial for improving the early detection of cognitive decline. This study aimed to investigate the association between cerebral cortical volume and performance on VFTs, specifically category (CFT) and letter (LFT) fluency tests, to identify brain regions associated with verbal fluency. In this cross-sectional observational study, community-dwelling adults underwent brain magnetic resonance imaging (MRI) and completed CFTs and LFTs. Participants with organic brain anomalies on MRI were excluded. Using multiple linear regression, the relationship, adjusted for age, sex, Mini-Mental State Examination score, and total brain volume, between local gray matter volumes in 22 cortical regions in both hemispheres and VFT performance was analyzed. We included 267 community-dwelling adults (70 years and 0.8 months ± 6 years and 2.3 months; 178 men and 89 women). A significant association was found between CFT scores and volume of the left inferior frontal gyrus (R

Indexed as

Cerebral CortexVerbal BehaviorAgedAtrophyCross-Sectional StudiesFemaleHumansIndependent LivingMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsOrgan SizeBrain atrophyCognitive impairmentInferior frontal gyrusMagnetic resonance imagingVerbal fluency test

Identifiers

PMID42709233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.