Evidence map›Paper›PMID 42709163›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2026

Sex-stratified associations between depressive symptoms and cognitive impairment in treatment-resistant vs. non-resistant schizophrenia.

Chuhao Zhang, Jingxuan Liu, Jian Zhang, Nannan Liu, Shaobing Li, Xinxu Wang, Yanzhe Li, Chenghao Lu, Jinghui Chi, Yonghui Zhang and 2 more

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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Chuhao Zhang *Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Jingxuan Liu *Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Jian Zhang *Department of Psychiatry, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Nannan LiuInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Shaobing LiInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Xinxu WangInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Yanzhe LiInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Chenghao LuInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Jinghui ChiInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China.
Yonghui ZhangDepartment of Psychiatry, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China. zhangyonghuisk@163.com.
Shen LiInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China. lishen@tmu.edu.cn.ORCID https://orcid.org/0000-0002-7157-7945
Jie LiInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Rd., Hexi District, Tianjin, 300222, China. jieli@tmu.edu.cn.

Funding

China Association for Pharmaceutical Education P2026010800296National Natural Science Foundation of China 82371512National Natural Science Foundation of China 82571719Tianjin Health Research Project TJWJ2024MS037Tianjin Key Medical Discipline Construction Project TJYXZDXK-3-015BTianjin Major Special Project on Public Health Science and Technology 25ZXWQSY00100
6 · The paper itself

Abstract

backgroundTreatment-resistant schizophrenia (TRS), affecting approximately 30% of schizophrenia patients, is frequently accompanied by depressive symptoms, which exacerbate cognitive and socio-emotional deficits. However, it remains unclear whether the impact of depressive symptoms on cognition differs by sex in TRS patients.

methodsWe evaluated 344 schizophrenia patients (112 TRS, 232 non-TRS) at Tianjin Anding Hospital. Depressive symptoms were assessed with the Hamilton Depression Rating Scale (HAMD), cognitive function with the Repeatable Battery for Neuropsychological Status (RBANS), and alexithymia with the Toronto Alexithymia Scale-26 (TAS-26). Two-way ANCOVA examined diagnosis-by-sex interactions, and partial correlation analyses assessed sex-stratified associations between depressive symptoms and cognitive and emotional measures. FDR correction was applied for all partial correlation analyses.

resultsCompared to females, males showed better performance on verbal tasks and higher TAS-26 scores, specifically in identifying, describing, and externally orienting emotions (all p

conclusionOur findings indicate that the associations between depressive symptoms and alexithymia differ between males and females in schizophrenia, with distinct patterns observed across TRS and non-TRS patients.

Indexed as

AlexithymiaDepressive symptomNeurocognitionSex differencesTreatment-resistant schizophrenia

Identifiers

PMID42709163

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